Human EMMPRIN / CD147 Protein, Fc Tag

Cat. No. / Size
Price
Qty
CD7-H5259-100ug
$270.00
CD7-H5259-1mg (500ug X 2)
$1650.00
ETA of in-stock products:2 business days

Product Details

  • Synonyms

    Basigin, BSG, 5F7, CD147, EMMPRIN, M6, OK, TCSF

  • Source

    Human EMMPRIN, Fc Tag (CD7-H5259) is expressed from human 293 cells (HEK293). It contains AA Ala 22 - His 205 (Accession # P35613-2).

    Predicted N-terminus: Ala 22

    Request for sequence
  • Molecular Characterization

    EMMPRIN Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 46.3 kDa. The protein migrates as 55-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Shipping and Storage

    This product is shipped at ambient temperature.

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    EMMPRIN SDS-PAGE

    Human EMMPRIN, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

  • Bioactivity-ELISA

     EMMPRIN ELISA

    Immobilized Human EMMPRIN, Fc Tag (Cat. No. CD7-H5259) at 1 μg/mL (100 μL/well) can bind Anti-EMMPRIN Antibody, Mouse IgG1 with a linear range of 0.2-4 ng/mL (QC tested).

    Protocol

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Background

CD147, also known as Basigin (BSG), or extracellular matrix metalloproteinase inducer (EMMPRIN). The human basigin protein contains 269 amino acids that form two heavily glycosylated C2 type immunoglobulin-like domains at the N-terminal extracellular portion. A second form of basigin has also been characterized that contains one additional immunoglobulin-like domain in its extracellular portion. As members of the immunoglobulin superfamily play fundamental roles in intercellular recognition involved in various immunologic phenomena, differentiation, and development, basigin is thought also to play a role in intercellular recognition and regulate several distinct functions, such as spermatogenesis, expression of the monocarboxylate transporter and the responsiveness of lymphocytes. Basigin is a type I integral membrane receptor that has many ligands, including the cyclophilin (CyP) proteins Cyp-A and CyP-B and certain integrins.

Recent Advances

 
Drug Development Progress
  • English Name:

    Basigin

  • Category:

  • Approved Drugs:

    1 Details

  • Drugs in Clinical Trials:

    4 Details

  • Highest Development Stage:

    Approved

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