Human COMP / TSP5 Protein, His Tag

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Cat. No. / Size
Price
Qty
COP-H5220-100ug
$285.00
COP-H5220-1mg (500ug X 2)
$1870.00
ETA of in-stock products:2 business days

Product Details

  • Synonyms

    COMP, TSP5, EDM1, EPD1, MED, PSACH, THBS5

  • Source

    Human COMP, His Tag (COP-H5220) is expressed from human 293 cells (HEK293). It contains AA Gln 21 - Ala 757 (Accession # AAI25093).

    Predicted N-terminus: Gln 21

    Request for sequence
  • Molecular Characterization

    COMP Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 81.9 kDa. The protein migrates as 90-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 0.1 EU per μg by the LAL method / rFC method.

  • Purity

    >85% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Shipping and Storage

    This product is shipped at ambient temperature.

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    COMP SDS-PAGE

    Human COMP, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 85%.

  • Bioactivity-CELL BASE

     COMP CELL

    Human COMP / TSP5 Protein, His Tag (Cat. No. COP-H5220) induces the adhesion of ATDC5 cells. The EC50 value of this effect is 1.775 μg/mL (Routinely tested).

    Protocol

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Background

Cartilage oligomeric matrix protein (COMP) is also known as Thrombospondin-5 (TSP5), EDM1, EPD1, MED, PSACH, THBS5, which belongs to the thrombospondin family. COMP / TSP5 contains 4 EGF-like domains, 1 TSP C-terminal (TSPC) domain, 8 TSP type-3 repeats. Abundantly expressed in the chondrocyte extracellular matrix, and is also found in bone, tendon, ligament and synovium and blood vessels. COMP may play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. COMP can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Thrombospondin-5 could play a role in the pathogenesis of osteoarthritis. COMP is a marker of cartilage turnover.

Recent Advances

 
Drug Development Progress
  • English Name:

    Sodium channel protein type VIII alpha subunit

  • Category:

  • Approved Drugs:

    1 Details

  • Drugs in Clinical Trials:

    3 Details

  • Highest Development Stage:

    Approved

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