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Your Position: Home > Protein > IL-35 R > ILR-H52H8

Human IL-35 R / gp130 & IL12Rb2 Protein, His Tag (MALS verified)

  • Synonym
    IL-35 R,gp130 & IL12Rb2,CD130 & IL12Rb2,IL-6RB & IL12Rb2,gp130 & IL12Rb2
  • Source
    Human IL-35 R, His Tag(ILR-H52H8) is expressed from human 293 cells (HEK293). It contains AA Glu 23 - Glu 619 & Lys 24 - Asn 622 (Accession # P40189-1 (gp130) & Q99665-1 (IL12Rb2)).
    Predicted N-terminus: Glu 23 & Lys 24
  • Molecular Characterization

    This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 73.1 kDa | 71.5 kDa. The protein migrates as 85-110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.

Human IL-35 R, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

IL-35 R MALS images

The purity of Human IL-35 R, His Tag (Cat. No. ILR-H52H8) is more than 90% and the molecular weight of this protein is around 175-205 kDa verified by SEC-MALS.


Immobilized Human IL-35 R, His Tag (Cat. No. ILR-H52H8) at 5 μg/mL (100 μL/well) can bind Human IL-35, Fc Tag (Cat. No. IL5-H5259) with a linear range of 0.002-0.625 μg/mL (QC tested).

  • Background
    Interleukin 35 (IL-35) is a recently discovered anti-inflammatory cytokine from the IL-12 family. Member of IL-12 family - IL-35 is produced by wide range of regulatory lymphocytes and plays a role in immune suppression. IL-35 can block the development of Th1 and Th17 cells by limiting early T cell proliferation. The heterodimeric cytokine of IL-35 involves two subunits of p35 and Ebi3 which are also seen in IL-12 and IL-27. IL-35 is recognized as a defi nite immunosuppressor with a huge potent of suppression.
  • Clinical and Translational Updates
  • Please contact us via if you have any question on this product.

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