Monoclonal Anti-Human IgG Fc Antibody, Mouse IgG1 (6F11C8)

Source

Chimeric Monoclonal Anti-Human IgG Fc Antibody, Mouse IgG1 (6F11C8) is recombinantly expressed in CHO. It consists of mouse variable regions genetically fused to mouse IgG1 constant domains.

Antibody Type

Recombinant Monoclonal

Clone

6F11C8

Isotype

Mouse IgG1, Kappa

Host Species

Mouse

Reactivity

Human IgG Fc, including IgG1–IgG4 isotypes and Fc-engineered variants (e.g. N297A, LALA, YTE, LS, S239D/I332E)

Immunogen

Recombinant Human Fc derived from CHO cells

Specificity

Specifically binds to the Fc region of human IgG without recognizing Fab fragments or mouse IgG isotypes.

Application

Cross Verification

Positive: Cross-reactive by ELISA with human IgG subclasses (IgG1, IgG2, IgG3, IgG4) and a panel of Fc-engineered variants including N297A, LALA, YTE, LS, S239D/I332E. Weak cross-reactivity by ELISA with cynomolgus IgG.
Negative: No detectable cross-reactivity by ELISA with mouse IgG subclasses (IgG1, IgG2a, IgG2b).

Purification

Protein A purified.

Aggregation

Less than 10%, as determined by SEC-MALS.

Concentration

Please refer to the Certificate of Analysis (CoA).

Form

Lyophilized

Formulation

Lyophilized from a 0.22 μm-filtered solution in PBS, with trehalose as protectant.

Please contact us for customized product forms or formulations.

Reconstitution

Please refer to the Certificate of Analysis (CoA) for specific instructions.

Shipping

Lyophilized product is shipped at ambient temperature.

Storage

For long term storage, the product should be stored in a lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

1. -20°C to -70°C for 12 months in lyophilized state;
2. -70°C for 3 months under sterile conditions after reconstitution.

Notices

Product Specific Notices: For research use only.

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2. Quality Advantages
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