Mouse MMP-8 Protein, His Tag (Pro-form, MALS verified)

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Cat. No. / Size
Price
Qty
MM8-M52H7-50ug
$360.00
MM8-M52H7-1mg
$2225.00
ETA of in-stock products:2 business days

Product Details

  • Synonyms

    CLG1 Protein, HNC Protein, MMP-8 Protein, PMNL-CL Protein,

  • Source

    Mouse MMP-8 Protein, His Tag (MM8-M52H7) is expressed from human 293 cells (HEK293). It contains AA Phe 21 - Gly 262 (Accession # O70138-1). It needs to be activated by agents such as APMA in vitro to have hydrolytic activity.

    Predicted N-terminus: Phe 21

    Request for sequence

  • Molecular Characterization

    MMP-8 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 28.9 kDa. The protein migrates as 35-40 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

    >95% as determined by SEC-MALS.

  • Formulation

    Supplied as 0.2 μm filtered solution in 25 mM MES, 150 mM NaCl, Glycerol, pH5.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Shipping

    This product is supplied and shipped with dry ice, please inquire the shipping cost.

  • Storage

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. The product MUST be stored at -70°C or lower upon receipt;
    2. -70°C for 3 months under sterile conditions.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    MMP-8 SDS-PAGE

    Mouse MMP-8 Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    MMP-8 SEC-MALS

    The purity of Mouse MMP-8 Protein, His Tag (Cat. No. MM8-M52H7) is more than 95% and the molecular weight of this protein is around 28-40 kDa verified by SEC-MALS.

    Report
  • Bioactivity

    Measured by its ability to cleave a fluorogenic peptide substrate Mca-KPLGL-Dpa-AR-NH2. The specific activity is >700 pmol/min/µg (QC tested).

    Protocol

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Background

Matrix metalloproteinase-8(MMP-8)also known as neutrophil collagenase and CLG1,is a member of matrix metalloproteinases (MMPs) family,which degrade components of the extracellular matrix (ECM) and play essential roles in various physiological processes as well as pathological processes. MMP-8 may affect the metastatic behavior of breast cancer cells through protection against lymph node metastasis, underlining the importance of anti-target identification in drug development. MMP-8 in the tumor may have a protective effect against lymph node metastasis.

Recent Advances

 
Drug Development Progress
  • English Name:

    Matrix metalloproteinase 8

  • Category:

  • Approved Drugs:

    0 Details

  • Drugs in Clinical Trials:

    0 Details

  • Highest Development Stage:

    Preclinical

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