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Product Details
Synonyms
Tyk2, tyrosine kinase 2
Source
Human Tyk2 Protein, His Tag (TY2-H5547) is expressed from Baculovirus-Insect cells. It contains AA Pro 871 - Cys 1187 (Accession # P29597-1).
Predicted N-terminus: His
Request for sequenceMolecular Characterization
Other Tags and Version Biotin & Other Labeled Version
This protein carries a polyhistidine tag at the N-terminus.
The protein has a calculated MW of 38.5 kDa.
Endotoxin
Less than 1.0 EU per μg by the LAL method / rFC method.
Formulation
Supplied as 0.2 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH7.5 with glycerol as protectant.
Contact us for customized product form or formulation.
Shipping
This product is supplied and shipped with dry ice, please inquire the shipping cost.
Storage
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
- The product MUST be stored at -70°C or lower upon receipt;
- -70°C for 3 months under sterile conditions.
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Performance Data
Bioactivity
The Tyk2 assay is performed using the ADP-GloTM Kinase Assay kit which quantifies the amount of ADP produced by the Tyk2 reaction. The ADP- GloTM Reagent is added to terminate the kinase reaction and to deplete the remaining ATP, and then the Kinase Detection Reagent is added to convert ADP to ATP and to measure the newly synthesized ATP using luciferase/luciferin reaction.The specific activity is >400 pmol/min/mg (QC tested).
Protocol
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Background
Recent Advances
Drug Development Progress- English Name：
Tyrosine-protein kinase 2
- Category：
- Approved Drugs：
3 Details
- Drugs in Clinical Trials：
47 Details
- Highest Development Stage：
Approved
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