Human TWEAK R / TNFRSF12A Protein, Fc Tag (SPR verified)

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Cat. No. / Size
Price
Qty
TNA-H526a-100ug
$285.00
TNA-H526a-1mg
$1815.00
ETA of in-stock products:2 business days

Product Details

  • Synonyms

    TNFRSF12A, FGF-inducible 14, FN14, TweakR, CD266

  • Source

    Human TWEAK R, Fc Tag (TNA-H526a) is expressed from human 293 cells (HEK293). It contains AA Glu 28 - Trp 79 (Accession # AAH02718).

    Predicted N-terminus: 0

    Request for sequence
  • Molecular Characterization

    TWEAK R Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a human IgG1 Fc tag at the N-terminus.

    The protein has a calculated MW of 32.5 kDa. The protein migrates as 38-40 kDa under reducing (R) condition, and 65-80 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Shipping and Storage

    This product is shipped at ambient temperature.

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    TWEAK R SDS-PAGE

    Human TWEAK R, Fc Tag on SDS-PAGE under reducing (R) and non-reducing (NR) conditions. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • Bioactivity-SPR

     TWEAK R SPR

    Human TWEAK Protein, Fc Tag (Cat. No. TWK-H5263) immobilized on CM5 Chip can bind Human TWEAK R, Fc Tag (Cat. No. TNA-H526a) with an affinity constant of 42.8 pM as determined in a SPR assay (Biacore 8K) (QC tested).

    Protocol

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Background

Tumor necrosis factor receptor superfamily member 12A (TNFRSF12A) is also known as Fibroblast growth factor-inducible immediate-early response protein 14 (FN14 or FGF-inducible 14), Tweak-receptor, CD antigen CD266. TNFRSF12A contains one TNFR-Cys repeat. TNFRSF12A is highly expressed in heart, placenta and kidney. TNFRSF12A is receptor for TNFSF12/TWEAK, and is weak inducer of apoptosis in some cell types. TNFRSF12A / FN14 promotes angiogenesis and the proliferation of endothelial cells.

Recent Advances

 
Drug Development Progress
  • English Name:

    Tumor necrosis factor receptor superfamily member 12A

  • Category:

  • Approved Drugs:

    0 Details

  • Drugs in Clinical Trials:

    0 Details

  • Highest Development Stage:

    Pending

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