Human Transthyretin / Prealbumin Protein, His Tag

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Cat. No. / Size
Price
Qty
TTR-H5223-100ug
$285.00
TTR-H5223-1mg (500ug X 2)
$1870.00
ETA of in-stock products:2 business days

Product Details

  • Synonyms

    Transthyretin, TTR, Prealbumin, TBPA, ATTR, PALB, CTS, CTS1, HsT2651

  • Source

    Human Transthyretin, His Tag (TTR-H5223) is expressed from human 293 cells (HEK293). It contains AA Gly 21 - Glu 147 (Accession # NP_000362).

    Predicted N-terminus: Gly 21

    Request for sequence
  • Molecular Characterization

    Transthyretin Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 14.9 kDa. The protein migrates as 17 kDa and 33 kDa under reducing (R) condition (SDS-PAGE) due to the monomer and dimer respectively.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Shipping and Storage

    This product is shipped at ambient temperature.

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    Transthyretin SDS-PAGE

    Human Transthyretin, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

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Background

Transthyretin (TTR) is also known as Prealbumin, ATTR, TBPA, PALB, which belongs to the transthyretin family. Transthyretin / TTR is a serum and cerebrospinal fluid carrier of the thyroid hormone thyroxine (T4) and retinol-binding protein bound to retinol. In cerebrospinal fluid TTR is the primary carrier of T4. TTR also acts as a carrier of retinol (vitamin A) through its association with retinol-binding protein (RBP) in the blood and the CSF. Less than 1% of TTR's T4 binding sites are occupied in blood. TTR misfolding and aggregation is known to be associated with the amyloid diseases.

Recent Advances

 
Drug Development Progress
  • English Name:

    Transthyretin

  • Category:

  • Approved Drugs:

    7 Details

  • Drugs in Clinical Trials:

    9 Details

  • Highest Development Stage:

    Approved

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