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Home PageAll MoleculesALPP
ALPP
ALPP Overview
| English Name | Alkaline phosphatase, placental type | Approved Drugs | 0 |
| Drugs in Clinical Trials | 2 | Target Synonym | Alkaline phosphatase Regan isozyme，Placental alkaline phosphatase 1，PLAP-1 |
| Highest Development Stage | Phase 2 Clinical | ||
| English Name | Alkaline phosphatase, placental type |
| Target Synonym | Alkaline phosphatase Regan isozyme，Placental alkaline phosphatase 1，PLAP-1 |
| Approved Drugs | 0 |
| Drugs in Clinical Trials | 2 |
| Highest Development Stage | Phase 2 Clinical |
ALPP Product List
- Product Category
Protein (4)Antibody (1)
- Product Status
Launched (5)
- Species
Cynomolgus (1)Human (2)Mouse (1)Rat (1)
- Tag
His Tag (3)- (1)His Tag & Avi Tag (1)
- Conjugate
Unconjugated (4)Biotin-labeled (1)
| Cat. No. | Species | Host | Product Description | Structure | Purity | Feature | Order Now |
|---|---|---|---|---|---|---|---|
HOT ALP-H52H3 |  Human | HEK293 | Human ALPP Protein, His Tag (active enzyme, MALS verified) |  |  |  |  Add to Cart |
HOT ALP-H82E3 | Human | HEK293 | Biotinylated Human ALPP Protein, His,Avitag™ (active enzyme, MALS verified) |  | | | Add to Cart |
HOT ALP-R52H4 |  Rat | HEK293 | Rat ALPP Protein, His Tag (active enzyme) |  | | | Add to Cart |
 Mouse | - | Recombinant Monoclonal Anti-ALPP Antibody, Mouse (1B10) | Add to Cart | ||||
 Cynomolgus | HEK293 | Cynomolgus ALPP Protein, His Tag (active enzyme) |  | | | Add to Cart |
Total: 5
- 1
ALPP Background
Placental alkaline phosphatase (ALPP) is a membrane-bound enzyme normally restricted to placental tissue. However, it is aberrantly overexpressed in various solid tumors, including ovarian, testicular, and cervical cancers, making it a highly specific tumor biomarker. High-affinity anti-ALPP antibodies are essential for early clinical cancer diagnostics (IHC/serum screening) and the development of targeted therapies like antibody-drug conjugates (ADCs) and CAR-T cells.
ALPP Synonyms
PLAP
Clinical Drug Information
| English Name | Research Code | Highest Development Stage | Company | Indication | Clinical Trial |
|---|---|---|---|---|---|
| Retroviral vector-transduced autologous T cells to express anti-ALPP CARs (TCRCure Biopharma Corporation) | Phase 2 Clinical | Xinqiao Hospital, Army Medical University | Endometrial Neoplasms; Ovarian Neoplasms; Solid tumours | Details | |
| anti-ALPP CAR T-cell therapy (TCRCure Biopharma) | TC-A101 | Phase 1 Clinical | Tcrcure Biopharma Ltd | Solid tumours | Details |
- Product List
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