Select Language
Free Registration

B7-H4

B7-H4 Overview

English NameV-set domain-containing T-cell activation inhibitor 1Approved Drugs0
Drugs in Clinical Trials10Target SynonymV-Set Domain-Containing T-Cell Activation Inhibitor 1，Immune costimulatory protein B7-H4，B7h.5，B7 homolog 4，T-cell costimulatory molecule B7x，V-Set Domain Containing T Cell Activation Inhibitor 1，B7X，B7 Family Member， H4，T Cell Costimulatory Molecule B7x，B7S1，B7 Superfamily Member 1，VCTN1，PRO1291，FLJ22418，B7H4，B7-H4，Protein B7S1
Highest Development StagePhase 3 Clinical
English NameV-set domain-containing T-cell activation inhibitor 1
Target SynonymV-Set Domain-Containing T-Cell Activation Inhibitor 1，Immune costimulatory protein B7-H4，B7h.5，B7 homolog 4，T-cell costimulatory molecule B7x，V-Set Domain Containing T Cell Activation Inhibitor 1，B7X，B7 Family Member， H4，T Cell Costimulatory Molecule B7x，B7S1，B7 Superfamily Member 1，VCTN1，PRO1291，FLJ22418，B7H4，B7-H4，Protein B7S1
Approved Drugs0
Drugs in Clinical Trials10
Highest Development StagePhase 3 Clinical

B7-H4 Product List

  • Product Category

    Protein (9)Cell (1)

  • Product Status

    Launched (10)

  • Species

    Human (5)Mouse (2)Cynomolgus / Rhesus macaque (1)Rat (1)Canine (1)

  • Tag

    His Tag (7)His Tag & Avi Tag (1)Fc Tag (1)- (1)

  • Conjugate

    Unconjugated (6)Biotin-labeled (2)Azide Labeled (1)- (1)

Total: 10
  • 1

B7-H4 Background

V-set domain-containing T-cell activation inhibitor 1 (VTCN1) is also known as Immune costimulatory protein B7-H4, Protein B7S1, T-cell costimulatory molecule B7x, B7H4, which belongs to the immunoglobulin superfamily and BTN/MOG family. VTCN1 contains two Ig-like V-type (immunoglobulin-like) domains. The expression of VTCN1 is up-regulated by IL6 and IL10 and is inhibited by GM-CSF and IL4 on antigen-presenting cells (APCs). VTCN1 / B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. VTCN1 involved in promoting epithelial cell transformation.

B7-H4 Synonyms

B7-H4,VTCN1,B7S1,B7h.5

Product Reviews

  • 1***12019-11-16
    4People Like
    Biotinylated Human B7-H4 Protein, Avitag™,His Tag (recommended for biopanning) (MALS verified)
    We purchased total of 600ug of this biotin-labeled antigen for liquid phase panning and antibody screening of affinity maturation. This antigen has good stability, high quality, and high repeatability for each experiment. Using this antigen, we screened high-affinity antibodies against this target. And using this antigen for screening of affinity maturation, we obtained antibodies with 10-times increased affinity. I highly recommended this product.
  • Overview
  • Product List