BCMA

BCMA

BCMA Overview

Molecule Name
B-cell maturation protein
Synonyms
TNFRSF17,CD269,BCM,BCMA
Drug Development Progress
Drugs in Clinical Trials151
Approved Drugs8
Highest Development StageApproved
Target Synonym
B-Cell Maturation Protein,B-Cell Maturation Factor,B Cell Maturation Antigen,CD269 Antigen,Tumor Necrosis Factor Receptor Superfamily Member 17,TNFRSF17,TNFRSF13A,CD269,BCM,BCMA,TNF Receptor Superfamily Member 17,Tumor Necrosis Factor Receptor Superfamily, Member 17,B-Cell Maturation Antigen
Background
Tumor necrosis factor receptor superfamily member 17 (TNFRSF17) is also known as B-cell maturation protein (BCMA), CD antigen CD269, which is a member of the TNF-receptor superfamily. TNFRSF17 contains one TNFR-Cys repeat. TNFRSF17 is expressed in mature B-cells, but not in T-cells or monocytes. TNFRSF17 is receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. TNFRSF17 promotes B-cell survival and plays a role in the regulation of humoral immunity. TNFRSF17 can activate NF-kappa-B and JNK.

BCMA Product List

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  • C***e2026-09-03
    APC-Labeled Human BCMA (CAT# BCA-HA2H5-200tests) is well stocked with shipments typically less than 3 days after ordering. Our regional sales representative is very attentive and has been a useful resource in tracking orders when working on a tight schedule. The APC-Labeled Human BCMA works wonderfully. This is a directly conjugated material, thus no need for a secondary antibody so it can simply your experimental design and reduce the complexity of your experimental variables when designing your experiment's working range. A dilution series from their recommended 1:50, dilution sill performed well in flow cytometry well ~200 dilution (8x more dilute than recommended) and still detected positive cells at a 1:800 dilution (16-fold higher dilution than recommended) where I ended the titration series. Note- Your experimental setup may have different optimum dilutions, depending on your setup and goals. There was no non-specific binding, thus enabling minimal PBS washes and potentially allows for less cells to be utilized as some fraction will be lost each wash. I'm very pleased with the product, it will simplify assay design and reduce development time.
  • T***d2025-06-13
    Group used this product in a TE experiment on the MSD platform. Achieved a STD Curve range that was adequate for assay needs.
  • S***i2025-01-23
    We have repurchased this item dozens of time. This product is very effective for flow cytometry and we use it to help detect our BCMA CAR-T product.