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BTLA

BTLA Overview

English NameB- and T-lymphocyte attenuatorApproved Drugs0
Drugs in Clinical Trials6Target SynonymBTLA，B- and T-lymphocyte attenuator，B- and T-lymphocyte-associated protein，B And T Lymphocyte Associated，CD272 Antigen，BTLA1，CD272
Highest Development StagePhase 3 Clinical
English NameB- and T-lymphocyte attenuator
Target SynonymBTLA，B- and T-lymphocyte attenuator，B- and T-lymphocyte-associated protein，B And T Lymphocyte Associated，CD272 Antigen，BTLA1，CD272
Approved Drugs0
Drugs in Clinical Trials6
Highest Development StagePhase 3 Clinical

BTLA Product List

  • Product Category

    Protein (10)Cell (2)Antibody (1)

  • Product Status

    Launched (13)

  • Species

    Human (11)Mouse (2)

  • Tag

    Fc Tag (3)His Tag (3)Fc Tag & Avi Tag (1)Mouse IgG Fc Tag (1)His Tag & Avi Tag (2)- (3)

  • Conjugate

    Unconjugated (7)Biotin-labeled (3)- (2)PE Labeled (1)

Cat. No.SpeciesHostProduct DescriptionStructurePurityFeature
HOT
BTA-H52H3
Human
HEK293
Human BTLA (31-150) Protein, His Tag, low endotoxin (MALS verified)
HOT
BTA-H82E4
Human
HEK293
Biotinylated Human BTLA (31-150) Protein, His,Avitag™ (MALS verified)
HOT
BTA-H82E5
Human
HEK293
Biotinylated Human BTLA (31-150) (M105V, G138S, V148M) Protein, His,Avitag™ (MALS verified)
HOT
BTA-M52E2
Mouse
HEK293
Mouse BTLA Protein, His Tag
BTA-H5254
Human
HEK293
Human BTLA (31-150) (M105V, G138S, V148M) Protein, Fc Tag (MALS verified)
BTA-H5255
Human
HEK293
Human BTLA (31-134) Protein, Fc Tag
BTA-H5256
Human
HEK293
Human BTLA (31-150) Protein, Fc Tag (MALS verified)
BTA-H5258
Human
HEK293
Human BTLA (31-150) Protein, Mouse IgG2a Fc Tag, low endotoxin (MALS verified)
BTA-H52H5
Human
HEK293
Human BTLA (31-150) (M105V, G138S, V148M) Protein, His Tag (MALS verified)
BTA-H82F3
Human
HEK293
Biotinylated Human BTLA (31-150) Protein, Fc,Avitag™ (MALS verified)
Total: 13
  • 1
  • 2

BTLA Background

B- and T-lymphocyte attenuator (BTLA) is also known as B- and T-lymphocyte-associated protein, CD antigen CD272. BTLA contains one Ig-like V-type (immunoglobulin-like) domain. As a lymphocyte inhibitory receptor, BTLA / CD272 inhibits lymphocytes during immune response. BTLA / CD272 can interact with tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2, and interact with TNFRSF14/HVEM.

BTLA Synonyms

BTLA,CD272

Clinical Drug Information

English NameResearch CodeHighest Development StageCompanyIndicationClinical Trial
TifcemalimabJS-004; TAB-004Phase 3 ClinicalShanghai Junshi Biosciences Co LtdCarcinoma, Renal Cell; Carcinoma, Transitional Cell; Esophageal Squamous Cell Carcinoma; Head and Neck Neoplasms; Hodgkin Disease; Lung Neoplasms; Lymphoma; Melanoma; Nasopharyngeal Carcinoma; Neoplasms; Pancreatic Neoplasms; Small Cell Lung Carcinoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms
Details
MB-272MB272; GS-0272Phase 1 ClinicalMiroBio Ltd, University Of OxfordArthritis, Rheumatoid; Autoimmune Diseases
Details
ANB-032ANB-032Phase 1 ClinicalAnaptysbio IncDermatitis, Atopic; Eczema; Inflammation
Details
VenanprubartLY-3361237Phase 1 ClinicalEli Lilly And Company, Sanford-Burnham Medical Research InstituteLupus Erythematosus, Systemic; Psoriasis; Sjogren's Syndrome
Details
HFB200604 AIDHFB-200604-AID; HFB200604; HFB-200604; HFB200604 AIDPhase 1 ClinicalHiFiBiO TherapeuticsAutoimmune Diseases; Inflammation
Details
HFB-200603HFB-200603Phase 1 ClinicalHiFiBiO TherapeuticsCarcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Colorectal Neoplasms; Melanoma; Neoplasms; Stomach Neoplasms
Details
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