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Menu
Home PageAll MoleculesCA125
CA125
CA125 Overview
| English Name | Mucin-16 | Approved Drugs | 0 |
| Drugs in Clinical Trials | 11 | Target Synonym | Mucin-16 Short Isoform，Mucin-16 Long Isoform，Ovarian carcinoma antigen CA125，Ovarian cancer-related tumor marker CA125，MUC16，MUC-16，CA-125，Mucin 16， Cell Surface Associated，CA125，CA125 Ovarian Cancer Antigen，Mucin-16，CA-125 Antigen，FLJ14303 |
| Highest Development Stage | Phase 3 Clinical | ||
| English Name | Mucin-16 |
| Target Synonym | Mucin-16 Short Isoform，Mucin-16 Long Isoform，Ovarian carcinoma antigen CA125，Ovarian cancer-related tumor marker CA125，MUC16，MUC-16，CA-125，Mucin 16， Cell Surface Associated，CA125，CA125 Ovarian Cancer Antigen，Mucin-16，CA-125 Antigen，FLJ14303 |
| Approved Drugs | 0 |
| Drugs in Clinical Trials | 11 |
| Highest Development Stage | Phase 3 Clinical |
CA125 Product List
- Product Category
Protein (8)
- Product Status
Launched (8)
- Species
Human (3)Cynomolgus (2)Mouse (1)Rabbit (1)Rat (1)
- Tag
Fc Tag & Avi Tag (2)His Tag (5)His Tag & Avi Tag (1)
- Conjugate
Biotin-labeled (3)Unconjugated (5)
| Cat. No. | Species | Host | Product Description | Structure | Purity | Feature |
|---|---|---|---|---|---|---|
HOT CA5-H52H6 |  Human | HEK293 | Human CA125 / MUC16 (13810-14451) Protein, His Tag, low endotoxin (MALS verified) |  |  |  |
HOT CA5-H82F4 | Human | HEK293 | Biotinylated Human CA125 / MUC16 Protein, Fc,Avitag™ |  | | |
HOT CA5-H82F8 | Human | HEK293 | Biotinylated Human CA125 / MUC16 (13810-14451) Protein, Fc,Avitag™ |  | | |
CA5-M52H6 |  Mouse | HEK293 | Mouse CA125 / MUC16 Protein, His Tag (MALS verified) |  |  | |
CA5-C52H8 |  Cynomolgus | HEK293 | Cynomolgus CA125 / MUC16 Protein, His Tag, low endotoxin (MALS verified) |  | | |
CA5-C82E9 | Cynomolgus | HEK293 | Biotinylated Cynomolgus CA125 / MUC16 Protein, His,Avitag™ (MALS verified) |  | | |
CA5-R52H4 |  Rabbit | HEK293 | Rabbit CA125 / MUC16 Protein, His Tag |  | | |
CA5-R52H5 |  Rat | HEK293 | Rat CA125 Protein, His Tag (MALS verified) |  | |
Total: 8
- 1
CA125 Background
The CA125, also known as the MUC16, is a mucin protein that may be found in type I transmembrane or secreted forms that are used monitor the progress of epithelial ovarian cancer therapy. The CA 125 molecule is almost certainly a glycoprotein with a predominance of O-linkages. It is heterogeneous with regard to both size and charge, most likely due to continuous deglycosylation of side chains during its life-span in bodily fluids. It exists as a very large complex (perhaps as much as 4 million daltons) under natural conditions
CA125 Synonyms
CA125,CA-125,CA125MUC-16,FLJ14303,MUC16,mucin 16,mucin-16
Clinical Drug Information
| English Name | Research Code | Highest Development Stage | Company | Indication | Clinical Trial |
|---|---|---|---|---|---|
| Oregovomab | B43.13 | Phase 3 Clinical | Paladin Pharma | Abdominal Neoplasms; Carcinoma, Ovarian Epithelial; Fallopian Tube Neoplasms; Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Peritoneal Neoplasms | Details |
| EB-NK-FM (FRalpha/MUC16) | EB-NK-FM | Phase 2 Clinical | Beijing Biotech | Carcinoma, Ovarian Epithelial; Fallopian Tube Neoplasms; Peritoneal Neoplasms | Details |
| EB-NK-MM (MSLN/MUC16) | EB-NK-MM | Phase 2 Clinical | Beijing Biotech | Carcinoma, Ovarian Epithelial; Fallopian Tube Neoplasms; Peritoneal Neoplasms | Details |
| LBL-033 | LBL-033 | Phase 2 Clinical | Nanjing Leadsbiolabs Co Ltd | Neoplasms | Details |
| REGN-5668 | REGN-5668 | Phase 2 Clinical | Regeneron Pharmaceuticals Inc | Endometrial Neoplasms; Fallopian Tube Neoplasms; Ovarian Neoplasms; Peritoneal Neoplasms | Details |
| Ubamatamab | REGN-4018 | Phase 2 Clinical | Regeneron Pharmaceuticals Inc | Carcinoma, Non-Small-Cell Lung; Endometrial Neoplasms; Fallopian Tube Neoplasms; Neoplasms; Ovarian Neoplasms; Peritoneal Neoplasms | Details |
| PRGN-3005 | PRGN-3005 | Phase 1 Clinical | Precigen Inc | Esophageal Neoplasms; Fallopian Tube Neoplasms; Lymphoma, Non-Hodgkin; Ovarian Neoplasms; Peritoneal Neoplasms; Sarcoma; Uterine Cervical Neoplasms | Details |
| GB-5267 | GB-5267 | Phase 1 Clinical | Generate Biomedicines Inc | Ovarian Neoplasms | Details |
| HWK-016 | HWK-016 | Phase 1 Clinical | Wuxi Biologics Co Ltd | Endometrial Neoplasms; Ovarian Neoplasms; Uterine Cervical Neoplasms | Details |
| JCAR-020 | JCAR-020 | Phase 1 Clinical | Eureka Therapeutics Inc, Juno Therapeutics Inc, Memorial Sloan Kettering Cancer Center | Solid tumours | Details |
| Mucin-16 (MUC16) Protein Targeting Immune Cell Therapy(Regeneron Pharmaceutical) | 27T-51; 27T51 | Phase 1 Clinical | Regeneron Pharmaceuticals Inc | Carcinoma, Ovarian Epithelial; Fallopian Tube Neoplasms; Peritoneal Neoplasms | Details |
Product Reviews
E***e2025-08-07
0People LikeWe used Acro Biosystems' recombinant Human CA125 / MUC16 protein (Catalog #CA5-H52H6) as a target antigen for antibody screening and downstream validation. The protein was employed in both ELISA and FACS assays. In ELISA, we observed strong, dose-dependent binding with minimal background, which enabled clear differentiation of candidate clones. For FACS, we used the protein to confirm surface staining specificity on engineered cell lines, and the results were consistent and reproducible. I was particularly impressed with the proteins high purity.
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