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CD117
CD117 Overview
| English Name | Stem cell growth factor receptor | Approved Drugs | 17 |
| Drugs in Clinical Trials | 37 | Target Synonym | EC 2.7.10，EC:2.7.10.1，MASTC，KIT Proto-Oncogene Receptor Tyrosine Kinase，V-Kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene-Like Protein，p145 c-kit，SCFR，KIT，Proto-Oncogene C-Kit，Proto-Oncogene Tyrosine-Protein Kinase Kit，Soluble KIT Variant 1，C-Kit Protooncogene，CD117 Antigen，Piebald Trait，EC 2.7.10.1，C-Kit，CD117，Proto-Oncogene Proteins c-kit，Mast/stem cell growth factor receptor Kit，PBT，Piebald trait protein，Tyrosine-protein kinase Kit，KIT Proto-Oncogene， Receptor Tyrosine Kinase，v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog |
| Highest Development Stage | Approved | ||
| English Name | Stem cell growth factor receptor |
| Target Synonym | EC 2.7.10，EC:2.7.10.1，MASTC，KIT Proto-Oncogene Receptor Tyrosine Kinase，V-Kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene-Like Protein，p145 c-kit，SCFR，KIT，Proto-Oncogene C-Kit，Proto-Oncogene Tyrosine-Protein Kinase Kit，Soluble KIT Variant 1，C-Kit Protooncogene，CD117 Antigen，Piebald Trait，EC 2.7.10.1，C-Kit，CD117，Proto-Oncogene Proteins c-kit，Mast/stem cell growth factor receptor Kit，PBT，Piebald trait protein，Tyrosine-protein kinase Kit，KIT Proto-Oncogene， Receptor Tyrosine Kinase，v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog |
| Approved Drugs | 17 |
| Drugs in Clinical Trials | 37 |
| Highest Development Stage | Approved |
CD117 Product List
- Product Category
Protein (15)
- Product Status
Launched (15)
- Species
Human (6)Mouse (2)Rhesus macaque (1)Cynomolgus (3)Canis (1)White-tufted-ear marmoset (1)Guinea pig (1)
- Tag
His Tag (8)Fc Tag (4)His Tag & Avi Tag (3)
- Conjugate
Unconjugated (10)Biotin-labeled (3)APC Labeled (1)PE Labeled (1)
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Total: 15
- 1
- 2
CD117 Background
c-KIT activation has been shown to have oncogenic activity in gastrointestinal stromal tumors (GISTs), melanomas, lung cancer, and other tumor types. The targeted therapeutics nilotinib and sunitinib have shown efficacy in treating KIT overactive patients, and are in late-stage trials in melanoma and GIST. KIT overactivity can be the result of many genomic events from genomic amplification to overexpression to missense mutations. Missense mutations have been shown to be key players in mediating clinical response and acquired resistance in patients being treated with these targeted therapeutics.
CD117 Synonyms
CD117,SCFR,c-Kit,KIT
Clinical Drug Information
| English Name | Research Code | Highest Development Stage | Company | Indication | Clinical Trial |
|---|---|---|---|---|---|
| Barzolvolimab | CDX-0159 | Phase 3 Clinical | University Of Toronto - St. George Campus, Yale University | Chronic Urticaria; Dermatitis, Atopic; Eosinophilic Esophagitis; Prurigo Nodularis; Skin Diseases; Symptomatic Dermographism; Urticaria | Details |
| Seralutinib | PK-10571; GB-002 | Phase 3 Clinical | Gilead Sciences Inc | Pulmonary Arterial Hypertension | Details |
| Chiauranib | CS-2164; CS2164 | Phase 3 Clinical | Shenzhen Chipscreen Biosciences Co Ltd | Carcinoma, Hepatocellular; Carcinoma, Pancreatic Ductal; Lymphoma, Non-Hodgkin; Neoplasms; Ovarian Neoplasms; Sarcoma; Small Cell Lung Carcinoma; Solid tumours; Triple Negative Breast Neoplasms | Details |
| Bezuclastinib | PLX-9486; CGT-9486 | Phase 3 Clinical | Daiichi Sankyo Co Ltd | Gastrointestinal Stromal Tumors; Hematologic Neoplasms; Leukemia, Mast-Cell; Mastocytosis; Mastocytosis, Systemic; Neoplasm Metastasis | Details |
| oral enteric coated imatinib (Tenax Therapeutics) | TNX-201 (Tenax Therapeutics) | Phase 3 Clinical | PH Precision Med | Pulmonary Arterial Hypertension | Details |
| Sitravatinib | MG-516; MG-91516; MGCD-516; IND-155305; MGCD-0516 | Phase 3 Clinical | Mirati Therapeutics Inc | Biliary Tract Neoplasms; Breast Neoplasms; Carcinoma; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Endometrial Neoplasms; Esophageal Squamous Cell Carcinoma; Gastrointestinal Neoplasms; Hepatic Insufficiency; Kidney Neoplasms; Liposarcoma; Lung Diseases; Lung Neoplasms; Metastatic breast cancer; Neoplasms; Oral Squamous Cell Carcinoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms; Ureteral Neoplasms; Uterine Cervical Neoplasms; Uveal melanoma | Details |
| AZD-3229 | NB-003; NB003; AZD-3229; AZD3229 | Phase 3 Clinical | Astrazeneca Turkey | Gastrointestinal Stromal Tumors; Influenza B virus infection; Solid tumours | Details |
| Elenestinib | BLU-263 | Phase 3 Clinical | Blueprint Medicines Corp | Mastocytosis, Systemic | Details |
| Autologous Human C-Kit Cardiac Stem Cells (CSCs) II (ISCI / University of Miami Miller School of Medicine) | Phase 2 Clinical | Elpiscience (Shanghai) Biopharma Ltd, University Of Miami | Myocardial Infarction; Ventricular Dysfunction, Left | Details | |
| Telatinib | EOC-315; BAY-57-9352 | Phase 2 Clinical | Bayer AG | Solid tumours; Stomach Neoplasms | Details |
| Briquilimab | AMG-191; JSP-191; JSP191 | Phase 2 Clinical | Amgen Inc, National Heart, Lung And Blood Institute, Stanford University | Anemia, Sickle Cell; Asthma; Chronic Urticaria; Granulomatous Disease, Chronic; Immunologic Deficiency Syndromes; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Severe Combined Immunodeficiency | Details |
| BLU-808 | SAR-449028; BLU-808 | Phase 2 Clinical | Blueprint Medicines Corp | Chronic Urticaria; Conjunctivitis, Allergic | Details |
| DCC-3009 | DCC-3009 | Phase 2 Clinical | Deciphera Pharmaceuticals Inc | Gastrointestinal Stromal Tumors | Details |
| Sorafenib Tosylate/Comekibart | MG-D-1609 | Phase 2 Clinical | Metagone Biotech Inc | Solid tumours | Details |
| Opelkibart elmanitin | MGTA-117 | Phase 2 Clinical | Heidelberg Pharma AG | Leukemia, Myeloid, Acute; Myelodysplastic Syndromes | Details |
| Hydroxychloroquine/Sorafenib | Phase 2 Clinical | Vg Life Sciences | Ovarian Neoplasms; Solid tumours | Details | |
| 18F-Dasatinib | 18F-SKI-249380; [18F]-Fluoro-BMS-354825; [18F]Dasatinib; [18F]SKI-249380; [18F]Fluoro-BMS-354825 | Phase 1 Clinical | Memorial Sloan Kettering Cancer Center | Bone Marrow Neoplasms; Carcinoma; Diagnostic agents; Lymphoma; Melanoma; Neoplasms; Sarcoma | Details |
| anti-CD117 CAR-T cells (Poseida Therapeutics) | Phase 1 Clinical | Poseida Therapeutics Inc | Hematopoietic stem cell transplantation (HSCT); Leukemia, Myeloid, Acute | Details | |
| Tafetinib Malate | SIM-0702; SIM-1005; SIM-010603 | Phase 1 Clinical | Jiangsu Simcere Pharmaceutical Co Ltd, Jilin Boda Pharmaceutical Co Ltd, Nanjing Yoko Biomedical Co Ltd | Neoplasms | Details |
| BEAM-103 | BEAM-103 | Phase 1 Clinical | Beam Therapeutics Inc | Anemia, Sickle Cell; beta-Thalassemia | Details |
| DPH-001 | DPH-001; DPH001 | Phase 1 Clinical | Disruptive Pharma AB | Details | |
| ALY-301 | ALY-301; GTX-B001 | Phase 1 Clinical | Alys Pharmaceuticals Inc | Chronic Urticaria; Symptomatic Dermographism; Urticaria | Details |
| QBH-196 | QBH-196 | Phase 1 Clinical | Shenyang Pharmaceutical University | Solid tumours; Stomach Neoplasms | Details |
| ETN-101 | ETN101; ETN-101; MBP-11901 | Phase 1 Clinical | Etnova Therapeutics Corp | Carcinoma, Hepatocellular; Liver Neoplasms | Details |
| CSCJC-3456 | CSCJC3456; CSCJC-3456 | Phase 1 Clinical | Changshan ConjuChem BioPharmaceutical Research and Development (Hebei) Co Ltd, Hebei Changshan Biochemical Pharmaceutical Co Ltd | Solid tumours | Details |
| THB-335 | THB-335; THB335 | Phase 1 Clinical | Third Harmonic Bio | Inflammation | Details |
| ND-003 (NewDEL Biotech) | ND003 (NewDEL Biotech); ND-003 (NewDEL Biotech); ND003; JND-5932 | Phase 1 Clinical | Jinan University, Shenzhen NewDEL Biotech Co Ltd | Dermatitis, Atopic; Gastrointestinal Stromal Tumors; Idiopathic Pulmonary Fibrosis; Neoplasms; Pulmonary Fibrosis; Renal fibrosis; Renal Insufficiency, Chronic; Solid tumours | Details |
| CDX-622 | CDX-622 | Phase 1 Clinical | Celldex Therapeutics Inc | Asthma; Fibrosis; Hypersensitivity; Inflammation | Details |
| QX-013N | QX-013-N; QX013N | Phase 1 Clinical | Qyuns Therapeutics Co Ltd | Chronic Urticaria; Urticaria | Details |
| NN-2101 | NN-2101 | Phase 1 Clinical | Novelty Nobility Inc | Diabetic macular oedema; Diabetic Retinopathy; Retinal Diseases; Retinal Vein Occlusion; Wet Macular Degeneration | Details |
| NN-3201 | NN-3201 | Phase 1 Clinical | Novelty Nobility Inc | Carcinoma, Adenoid Cystic; Carcinoma, Renal Cell; Gastrointestinal Stromal Tumors; Leukemia, Myeloid, Acute; Neuroendocrine Tumors; Small Cell Lung Carcinoma; Uveal melanoma | Details |
| THB-001 | THB-001 | Phase 1 Clinical | Novartis Corp | Chronic Urticaria; Gastrointestinal Diseases; Respiratory Tract Diseases | Details |
| T-1301 | T-1301; DBPR-216; BPR-1J481; BPR1J481 | Phase 1 Clinical | Taivex Therapeutics Corp | Lymphoma; Solid tumours | Details |
| GS-0174 | GS-0174 | Phase 1 Clinical | Forty Seven Inc | Hematologic Neoplasms | Details |
| TR-64 | TR-64 | Phase 1 Clinical | Tarapeutics Science Inc | Gastrointestinal Stromal Tumors; Solid tumours | Details |
| AGX-0073 | AGX-0073 | Phase 1 Clinical | Shanghai Aojian Biological Technology Co Ltd | Solid tumours | Details |
| Sorafenib tosylate (Bio-Synectics) | BS-104 | Clinical | Bio-Synectics Inc | Details |
Marketed Drug Information
| English Name | Research Code | Highest Development Stage | Company | Earliest Brand Name | Earliest Approval Country | Earliest Indication | Earliest Approval Company | Earliest Approval Date | Indication | Clinical Trial |
|---|---|---|---|---|---|---|---|---|---|---|
| Anlotinib Dihydrochloride | AL-3818 | Approved | Advenchen Laboratories Llc, Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd | 福可维 | Mainland China | Carcinoma, Non-Small-Cell Lung | Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd | 2018-05-08 | Bile Duct Diseases; Bone Neoplasms; Breast Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Renal Cell; Colorectal Neoplasms; Craniopharyngioma; Endometrial Neoplasms; Esophageal Squamous Cell Carcinoma; Fallopian Tube Neoplasms; Gallbladder Neoplasms; Gastroenteropancreatic neuroendocrine tumor; Gastroesophageal Junction Neoplasms; Gastrointestinal Stromal Tumors; Glioma; Head and Neck Neoplasms; Hepatic Insufficiency; Leiomyosarcoma; Liver Dysfunction; Lung Diseases, Interstitial; Lung Neoplasms; Lymphoma, Large B-Cell, Diffuse; Medullary thyroid cancer (MTC); Melanoma; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Neoplasms; Neuroendocrine Tumors; Osteoma; Ovarian Neoplasms; Peritoneal Neoplasms; Sarcoma; Sarcoma, Alveolar Soft Part; Sarcoma, Synovial; Small Cell Lung Carcinoma; Solid tumours; Stomach Neoplasms; Thoracic Neoplasms; Thyroid Neoplasms; Urologic Neoplasms; Uterine Cervical Neoplasms | Details |
| Imatinib mesylate | CGP-57148B; CGP-57148; STI-571; QTI-571; CTI-571; VR325; AER-901; YD-312; TNX-201 | Approved | Novartis Pharma Ag | glivic, 格列卫, Gleevec, Ruvise, Glivec, Gleevec/Glivec | EU | Leukemia, Myelogenous, Chronic | Novartis Europharm Ltd | 2001-05-10 | Abdominal Neoplasms; Acute Lung Injury; Amyloidosis; Anemia, Sickle Cell; Angioimmunoblastic T-cell Lymphoma; Asthma; Brain Neoplasms; Breast Neoplasms; Breast Neoplasms, Male; Burkitt Lymphoma; Carcinoma, Adenoid Cystic; Carcinoma, Neuroendocrine; Carcinoma, Ovarian Epithelial; Central Nervous System Lymphoma; Chordoma; Chronic eosinophilic leukemia (CEL); CNS Embryonal Tumor; Colonic Neoplasms; Colorectal Neoplasms; Congenital Bone Marrow Failure Syndromes; Coronavirus Disease 2019 (COVID-19); Dermatofibrosarcoma; Desmoplastic Small Round Cell Tumor; Diabetes Mellitus, Type 1; Diabetic macular oedema; Dry Socket; Eosinophilia; Fallopian Tube Neoplasms; Fibroma; Fibrosarcoma; Gastrointestinal Stromal Tumors; Genital Diseases, Male; Genital Neoplasms, Male; Glioblastoma; Glioma; Graft vs Host Disease; Head and Neck Neoplasms; Hemangiopericytoma; Hematologic Neoplasms; Hematopoietic stem cell transplantation (HSCT); Histiocytoma, Malignant Fibrous; Hodgkin Disease; Hypereosinophilic Syndrome; Hypertension, Pul | Details |
| Lenvatinib Mesilate | E-7080; MK-7902; ER-203492-00 | Approved | Eisai Co Ltd | Kisplyx, Lenvima, Lenvima/Kisplyx, 乐卫玛 | United States | Thyroid Neoplasms | Eisai Inc | 2015-02-13 | Adenocarcinoma; Adenocarcinoma of Lung; Adenocarcinoma, Follicular; Biliary Tract Neoplasms; Breast Neoplasms; Carcinoma, Adenoid Cystic; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Cholangiocarcinoma; Endometrial Neoplasms; Esophageal Neoplasms; Gastrointestinal Stromal Tumors; Glioma; Hepatic Insufficiency; Liver Diseases; Liver Neoplasms; Lymphoma; Melanoma; Neoplasm Metastasis; Neoplasms; Neuroendocrine Tumors; Osteosarcoma; Ovarian Neoplasms; Paraganglioma; Pheochromocytoma; Renal Insufficiency; Solid tumours; Stomach Neoplasms; Thyroid Cancer, Papillary; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms; Uterine Cervical Neoplasms | Details |
| Regorafenib | DAST; BAY-73-4506 | Approved | Bayer AG | Stivarga, Resihance | United States | Colorectal Neoplasms | Bayer Healthcare Pharmaceuticals Inc | 2012-09-27 | Adenocarcinoma; Adenoma; Bile Duct Neoplasms; Carcinoma, Adenoid Cystic; Carcinoma, Hepatocellular; Carcinoma, Islet Cell; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Colonic Neoplasms; Colorectal Neoplasms; Esophageal adenocarcinoma; Esophageal Neoplasms; Fallopian Tube Neoplasms; Gastrinoma; Gastrointestinal Neoplasms; Gastrointestinal Stromal Tumors; Glucagonoma; Hemangiosarcoma; Insulinoma; Leukemia, Myeloid, Acute; Liver Neoplasms; Lung Neoplasms; Melanoma; Meningioma; Neoplasm Metastasis; Neoplasms; Osteosarcoma; Ovarian Neoplasms; Pancreatic Neoplasms; Peritoneal Neoplasms; Rectal Neoplasms; Sarcoma; Sarcoma, Ewing; Solid tumours; Somatostatinoma; Stomach Neoplasms; Thymoma; Thyroid Neoplasms | Details |
| Avapritinib | BLU-285; CS-3007 | Approved | Blueprint Medicines Corp | Ayvakit, Ayvakyt, 泰吉华, Taijihua | United States | Gastrointestinal Stromal Tumors | Blueprint Medicines Corp | 2020-01-09 | Adenocarcinoma; Breast Neoplasms; Central Nervous System Neoplasms; Colorectal Neoplasms; Esophageal Neoplasms; Gastrointestinal Stromal Tumors; Hematologic Neoplasms; Leukemia, Mast-Cell; Lung Neoplasms; Mastocytosis, Systemic; Melanoma; Sarcoma; Solid tumours; Stomach Neoplasms | Details |
| Vorolanib | CM-082; X-82; EYP-1901; XV-615 | Approved | Tyrogenex Inc | 伏美纳, DURAVYU™ | Mainland China | Carcinoma, Renal Cell | Betta Pharmaceuticals Co Ltd | 2023-06-07 | Adenocarcinoma; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Choroidal Neovascularization; Diabetic macular oedema; Diabetic Retinopathy; Eye Diseases; Gastroesophageal Junction Neoplasms; Kidney Neoplasms; Leukemia, Myeloid, Acute; Macular Degeneration; Melanoma; Neoplasms; Pancreatic Neoplasms; Retinal Degeneration; Retinal Diseases; Small Cell Lung Carcinoma; Solid tumours; Stomach Neoplasms; Wet Macular Degeneration | Details |
| Ripretinib | DCC-2618 | Approved | Deciphera Pharmaceuticals | Qinlock, 擎乐 | United States | Gastrointestinal Stromal Tumors | Deciphera Pharmaceuticals Llc | 2020-05-15 | Gastrointestinal Stromal Tumors; Mastocytosis, Systemic; Neoplasms | Details |
| Olverembatinib | D-824; GZD-824; APG-1351; GIBH-824; HQP-1351 | Approved | Guangzhou Institute Of Biomedicine And Health, Chinese Academy Of Sciences | 耐立克 | Mainland China | Leukemia, Myelogenous, Chronic; Leukemia, Myeloid, Accelerated Phase | Guangzhou Shunjian Biomedical Technology Co Ltd | 2021-11-25 | Gastrointestinal Stromal Tumors; Hepatic Insufficiency; Leukemia, Lymphoid; Leukemia, Myelogenous, Chronic; Leukemia, Myeloid; Leukemia, Myeloid, Accelerated Phase; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Solid tumours | Details |
| Ponatinib Hydrochloride | AP24534 hydrochloride; AP24534-HCL; AP24534 HCl; INCB-84344; AP-24534 | Approved | Ariad | 英可欣, Iclusig | United States | Leukemia, Myelogenous, Chronic; Precursor Cell Lymphoblastic Leukemia-Lymphoma | Ariad Pharmaceuticals Inc | 2012-12-14 | Adenocarcinoma of Lung; Blast Crisis; Carcinoma, Non-Small-Cell Lung; Common Bile Duct Neoplasms; Gastrointestinal Stromal Tumors; Glioblastoma; Head and Neck Neoplasms; Hematologic Neoplasms; Leukemia; Leukemia, Biphenotypic, Acute; Leukemia, Myelogenous, Chronic; Leukemia, Myeloid, Accelerated Phase; Leukemia, Myeloid, Acute; Leukemia, Myeloid, Chronic-Phase; Leukemia, Myelomonocytic, Chronic; Lymphoma; Medullary thyroid cancer (MTC); Philadelphia Chromosome; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Small Cell Lung Carcinoma; Solid tumours; Thyroid Neoplasms | Details |
| Sunitinib Malate | PNU-290940AD; PHA-290940AD; SCAI-003; SU-010398; SU-11248; GB-102; PHA-290940; PNU-290940; SU-011248-L-malate salt | Approved | Pfizer Inc | Sutent, 索坦 | United States | Gastrointestinal Stromal Tumors; Carcinoma, Renal Cell | Cppi Cv | 2006-01-26 | Abdominal Neoplasms; Adenocarcinoma; Adenocarcinoma, Follicular; Adenoma, Islet Cell; Adrenocortical Carcinoma; AIDS-Related Complex; Amyloidosis; Angioimmunoblastic T-cell Lymphoma; Astrocytoma; Barrett Esophagus; Brain metastases; Brain Neoplasms; Breast Neoplasms; Burkitt Lymphoma; Carcinoma; Carcinoma, Acinar Cell; Carcinoma, Adenoid Cystic; Carcinoma, Adenosquamous; Carcinoma, Embryonal; Carcinoma, Hepatocellular; Carcinoma, Islet Cell; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Papillary; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Central Nervous System Neoplasms; Choriocarcinoma; Chronic eosinophilic leukemia (CEL); Cognition Disorders; Colorectal Neoplasms; Diabetic macular oedema; Endodermal Sinus Tumor; Endometrial Neoplasms; Ependymoma; Esophageal Neoplasms; Fallopian Tube Neoplasms; Fibromatosis, Aggressive; Fibrosarcoma; Gastrointestinal Stromal Tumors; Germinoma; Glioblastoma; Glioma; Gliosarcoma; Head and Neck Neoplasms; Hemangi | Details |
| Dasatinib Hydrate | NSC-732517; BMS-354825 | Approved | Bristol-Myers Squibb Company | Spraysel, 施达赛, Spricel, Sprycel | United States | Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Myelogenous, Chronic | Bristol-Myers Squibb Company | 2006-06-28 | Adenocarcinoma, Clear Cell; Angioimmunoblastic T-cell Lymphoma; Astrocytoma; Blast Crisis; Bone metastases; Brain Neoplasms; Breast Neoplasms; Burkitt Lymphoma; Carcinoma, Basosquamous; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Carcinoma, Verrucous; Cholangiocarcinoma; Chondrosarcoma; Chordoma; Colonic Neoplasms; Coronavirus Disease 2019 (COVID-19); Cystadenocarcinoma; Endometrial Neoplasms; Fallopian Tube Neoplasms; Gastrointestinal Stromal Tumors; Giant Cell Tumor of Bone; Glioblastoma; Glioma; Gliosarcoma; Heart Arrest; Hemangiopericytoma; Hematologic Neoplasms; HIV Infections; Hodgkin Disease; Hormone-Resistant Prostate Neoplasms; Hypereosinophilic Syndrome; Hypopharyngeal Neoplasms; Idiopathic Pulmonary Fibrosis; Immunoproliferative Small Intestinal Disease; Intraocular Lymphoma; Laryngeal Diseases; Laryngeal Neoplasms; Leukemia; Leukemia, Hairy Cell; Leukemia, Large Granular Lymphocytic; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Lymphoid; Leukemia, Myel | Details |
| Pexidartinib | PLX-3397 | Approved | Daiichi Sankyo Co Ltd | Turalio | United States | Giant Cell Tumor of Tendon Sheath | Daiichi Sankyo Inc | 2019-08-02 | Arthritis, Rheumatoid; Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Giant Cell Tumor of Tendon Sheath; Giant Cell Tumors; Glioblastoma; Hodgkin Disease; Leukemia, Myeloid, Acute; Leukemia, Promyelocytic, Acute; Melanoma; Metastatic breast cancer; Neoplasm Metastasis; Neoplasms; Neurofibroma, Plexiform; Neurofibrosarcoma; Ovarian Neoplasms; Pancreatic Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prostatic Neoplasms; Sarcoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Synovitis, Pigmented Villonodular | Details |
| Pazopanib Hydrochloride | GSK-786034; GW-786034B; SB-786034; GW-786034 | Approved | Glaxosmithkline Plc, Novartis Pharma Ag | 维全特, Armala, Votrient, Patorma | United States | Carcinoma, Renal Cell; Sarcoma | Novartis Pharma Ag | 2009-10-19 | Adenocarcinoma, Follicular; Brain Neoplasms; Breast Neoplasms; Breast Neoplasms, Male; Carcinoma, Embryonal; Carcinoma, Hepatocellular; Carcinoma, Neuroendocrine; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Central Nervous System Neoplasms; Chondrosarcoma; Chondrosarcoma, Extraskeletal Myxoid; Choriocarcinoma; Colorectal Neoplasms; Dermatofibrosarcoma; Endodermal Sinus Tumor; Epistaxis; Fallopian Tube Neoplasms; Fibromatosis, Aggressive; Gastrinoma; Gastroenteropancreatic neuroendocrine tumor; Gastrointestinal Neoplasms; Gastrointestinal Stromal Tumors; Genital Neoplasms, Female; Germinoma; Glioblastoma; Glioma; Gliosarcoma; Glucagonoma; Hemangiosarcoma; Herpes Genitalis; Herpes Simplex; HIV Infections; Hormone-Resistant Prostate Neoplasms; Insulinoma; Leiomyosarcoma; Leukemia, Myeloid, Acute; Liposarcoma; Lung Neoplasms; Lymphoma; Macular Degeneration; Medullary thyroid cancer (MTC); Melanoma; Mesothelioma; Multiple Endocrine Neoplasia T | Details |
| Cabozantinib S-malate | XL-184; BMS-907351; RO7047650; RO-7047650 | Approved | Exelixis Inc | Cometriq, Cabometyx | United States | Thyroid Neoplasms; Carcinoma, Neuroendocrine | Exelixis Inc | 2012-11-29 | Adenocarcinoma, Clear Cell; Adenocarcinoma, Follicular; Adenoma, Islet Cell; Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Astrocytoma; Bile Duct Neoplasms; Bone metastases; Brain metastases; Brain Neoplasms; Breast Neoplasms; Carcinoma, Adenosquamous; Carcinoma, Endometrioid; Carcinoma, Hepatocellular; Carcinoma, Merkel Cell; Carcinoma, Neuroendocrine; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Papillary; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Central Nervous System Neoplasms; Cholangiocarcinoma; Colorectal Neoplasms; Endometrial Neoplasms; Fallopian Tube Neoplasms; Gastroenteropancreatic neuroendocrine tumor; Glioblastoma; Glioma; Gliosarcoma; Hepatic Insufficiency; Hepatoblastoma; HIV Infections; Kidney Neoplasms; Leiomyosarcoma; Leukemia, Myeloid, Acute; Lymphoma; Medullary thyroid cancer (MTC); Melanoma; Meningioma; Multiple Myeloma; Neoplasm Metastasis; Neoplasms; Neoplasms, Germ Cell and Embryonal; Neuroblastoma; Neuroendocrin | Details |
| Sorafenib Tosylate | NSC-724772; BAY-43-0006; BAY-43-9006; BAY-54-9085 | Approved | Onyx Pharmaceuticals Inc | Nexavar, 多吉美 | United States | Carcinoma, Renal Cell | Bayer Healthcare Pharmaceuticals Inc | 2005-12-01 | Abdominal Neoplasms; Adenocarcinoma; Angioimmunoblastic T-cell Lymphoma; Astrocytoma; Bile Duct Neoplasms; Brain Neoplasms; Breast Neoplasms; Breast Neoplasms, Male; Burkitt Lymphoma; Carcinoma; Carcinoma, Hepatocellular; Carcinoma, Islet Cell; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Carcinoma, Verrucous; Cholangiocarcinoma; Colonic Neoplasms; Esophageal Neoplasms; Facial Neoplasms; Fallopian Tube Neoplasms; Fibromatosis, Aggressive; Gallbladder Neoplasms; Gastrinoma; Gastroesophageal Junction Neoplasms; Gastrointestinal Neoplasms; Gastrointestinal Stromal Tumors; Glioblastoma; Gliosarcoma; Glucagonoma; Head and Neck Neoplasms; Heart Arrest; Hemangiosarcoma; Hepatopulmonary Syndrome; Histiocytoma, Malignant Fibrous; Hypertension, Portal; Hypopharyngeal Neoplasms; Insulinoma; Kidney Diseases; Kidney Neoplasms; Laryngeal Diseases; Laryngeal Neoplasms; Leiomyosarcoma; Leukemia, Basophilic, Acute; Leukemia, Eosin | Details |
| Famitinib Malate | SHR-1020 | Approved | Jiangsu Hengrui Medicine Co Ltd | 艾比特 | Mainland China | Uterine Cervical Neoplasms | Jiangsu Hengrui Medicine Co Ltd | 2025-05-27 | Adenocarcinoma; Biliary Tract Neoplasms; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Cholangiocarcinoma; Colorectal Neoplasms; Endometrial Neoplasms; Gastroenteropancreatic neuroendocrine tumor; Gastrointestinal Stromal Tumors; Genital Neoplasms, Female; Idiopathic Pulmonary Fibrosis; Lung Neoplasms; Metastatic breast cancer; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Neoplasms; Ovarian Neoplasms; Pancreatic neuroendocrine tumors (pNET); Small Cell Lung Carcinoma; Solid tumours; Thyroid Neoplasms; Triple Negative Breast Neoplasms; Urologic Neoplasms; Uterine Cervical Neoplasms | Details |
| Midostaurin | PKC-412; PKC-412A; CGP-41231; CGP-41251 | Approved | Novartis Pharma Ag | Rydapt | United States | Hematologic Neoplasms; Leukemia, Myeloid, Acute; Mastocytosis, Systemic; Leukemia, Mast-Cell | Novartis Pharmaceuticals Corp | 2017-04-28 | Hematologic Neoplasms; Hepatic Insufficiency; Leukemia; Leukemia, Mast-Cell; Leukemia, Myeloid, Acute; Mastocytosis; Mastocytosis, Systemic; Myelodysplastic Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma | Details |
Product Reviews
V***l2022-06-25
0People LikeWe used the c-Kit protein to immunizations projects we are carrying for our studies and they performed great. The delivery was also very fast and the purchasing process very easy. We also purchased several other antibodies and recombinant proteins that we are currently testing and they all have very good quality. I have not used directly the technical services because it was not necessary, as the website is very easy and informative, so I found the products we wanted with no problem.
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[North America]: +1 800-810-0816
[Switzerland]: +41 800 040 012
[Asia & Pacific]: +86 400-682-2521
[North America]: 1 Innovation Way, Newark, DE 19711, USA
[Switzerland]: ACRObiosystems AG, c/o Zug Dammstrasse Centre AG, Dammstrasse 19, 6300 Zug Switzerland