DNase I Overview
Molecule Name
Deoxyribonuclease 1
Synonyms
DNase I,Deoxyribonuclease-1,Deoxyribonuclease I
Drug Development Progress
Drugs in Clinical Trials1
Approved Drugs1
Highest Development StageApproved
Target Synonym
EC:3.1.21.1，Deoxyribonuclease I，Dornase alfa，DNase I， Lysosomal，DNase I，DNL1，DNASE1，Deoxyribonuclease 1，DRNI，Human Urine Deoxyribonuclease I，Deoxyribonuclease-1，EC 3.1.21.1
Background
Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs. Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA (By similarity). Among other functions, seems to be involved in cell death by apoptosis. Binds specifically to G-actin and blocks actin polymerization. Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs) (By similarity). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity).
DNase I Product List
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Clinical Drug Information
| English Name | Research Code | Highest Development Stage | Company | Indication | Clinical Trial |
|---|---|---|---|---|---|
| repurposed deoxyribonuclease I (Human Microbiology Institute) | Clinical | Alzheimer Disease | Details |
Marketed Drug Information
| English Name | Research Code | Highest Development Stage | Company | First Brand Name | First Approved Country | First Indication | First Approved Company | First Approved Date | Indication | Clinical Trial |
|---|---|---|---|---|---|---|---|---|---|---|
| Chorionic Gonadotropin | LDI-200 | Approved | Angiogene Pharmaceuticals | Prostatic Neoplasms; Leukemia, Myeloid, Acute; Infertility, Female; Hypogonadism; Cryptorchidism | Details |