Select Language
EDNRB
EDNRB Overview
| English Name | Endothelin receptor type B | Approved Drugs | 5 |
| Drugs in Clinical Trials | 5 | Target Synonym | Hirschsprung Disease 2，Endothelin receptor non-selective type，ET-B，Endothelin receptor type B，EDNRB，ET-BR，ETRB，Endothelin Receptor Subtype B1，ABCDS，HSCR2，ETB1，ETBR，WS4A，HSCR，ETB，Receptor， Endothelin B |
| Highest Development Stage | Approved | ||
| English Name | Endothelin receptor type B |
| Target Synonym | Hirschsprung Disease 2，Endothelin receptor non-selective type，ET-B，Endothelin receptor type B，EDNRB，ET-BR，ETRB，Endothelin Receptor Subtype B1，ABCDS，HSCR2，ETB1，ETBR，WS4A，HSCR，ETB，Receptor， Endothelin B |
| Approved Drugs | 5 |
| Drugs in Clinical Trials | 5 |
| Highest Development Stage | Approved |
EDNRB Product List
- Product Category
Protein (4)
- Product Status
Launched (4)
- Species
Human (4)
- Tag
- (2)GFP Tag (1)His Tag & Flag Tag (1)
- Conjugate
Unconjugated (3)GFP Fusion (1)
| Cat. No. | Species | Host | Product Description | Structure | Purity | Feature | Order Now |
|---|---|---|---|---|---|---|---|
EDB-H52D3 |  Human | HEK293 | Human EDNRB Protein, Flag,His Tag (Detergent) |  |  |  |  Add to Cart |
EDB-H52D4 | Human | E. coli | Human EDNRB Full Length Protein, His,Flag Tag (Detergent) |  | | Add to Cart | |
EDB-H52P7 | Human | HEK293 | Human EDNRB Full Length Protein (VLP) | | Add to Cart | ||
EDB-HF2G4 | Human | HEK293 | Fluorescent Human EDNRB Full Length Protein (VLP) | | Add to Cart |
Total: 4
- 1
EDNRB Background
Endothelin Receptor B (EDNRB) is a type of G protein-coupled Receptor with the N-terminus located outside the cell. It's widespread in the human body. EDNRB binds to ET and transmits information into the cell through the intracellular Ca2+ phospholipid-dependent protein kinase second messenger system, which promotes the rapid release of calcium in the endoplasmic reticulum and sarcoplasmic reticulum, resulting in the rapid increase of intracellular calcium concentration. Endothelin exerts its biological effects through its receptor (ETR). Endothelin and ETR constitute the endothelin axis. Endothelin axis has pro-tumor effects in various tumors including malignant melanoma (MM), including promoting tumor growth, anti-apoptosis, promoting angiogenesis and promoting tumor metastasis.
EDNRB Synonyms
EDNRB,endothelin receptor type B,ABCDS, ET-B, ET-BR, ETB, ETB1, ETBR, ETRB, HSCR, HSCR2, WS4A
Clinical Drug Information
| English Name | Research Code | Highest Development Stage | Company | Indication | Clinical Trial |
|---|---|---|---|---|---|
| VRP-1620 | VRP-1620 | Phase 3 Clinical | University Of Illinois | Breast Neoplasms | Details |
| Vodudeutentan | ENB-003; ENB-006 | Phase 2 Clinical | Enb Therapeutics Inc | Melanoma; Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Solid tumours | Details |
| BQ-788 | BQ-788 | Phase 1 Clinical | Merck Serono | Cardiovascular Diseases; Hypertension; Melanoma | Details |
| GLX-002 | GLX-002; GLX002 | Phase 1 Clinical | Yabao Pharmaceutical Co Ltd Beijing | Pulmonary Arterial Hypertension | Details |
| Bosentan Orally Disintegrating Tablets(Beijing Sunho Pharma) | Phase 1 Clinical | Beijing Sunho Pharmaceutical Co Ltd | Pulmonary Arterial Hypertension | Details |
Marketed Drug Information
| English Name | Research Code | Highest Development Stage | Company | Earliest Brand Name | Earliest Approval Country | Earliest Indication | Earliest Approval Company | Earliest Approval Date | Indication | Clinical Trial |
|---|---|---|---|---|---|---|---|---|---|---|
| Sovateltide | IRL-1620; PMZ-1620; SPI-1620 | Approved | University Of Illinois At Chicago | Tyvalzi | India | Stroke | Pharmazz Inc | 2023-05-31 | Alzheimer Disease; Asphyxia Neonatorum; Biliary Tract Neoplasms; Brain Diseases; Brain Ischemia; Carcinoma; Carcinoma, Non-Small-Cell Lung; Cerebral Infarction; Dementia; Ischemic Stroke; Spinal Cord Injuries; Stroke | Details |
| Macitentan/Tadalafil | Approved | Actelion Pharmaceuticals Ltd | OPSYNVI, Yuvanci | United States | Pulmonary Arterial Hypertension | Actelion Pharmaceuticals Us Inc | 2024-03-22 | Phenylketonurias; Pulmonary Arterial Hypertension | Details | |
| Bosentan Hydrate | ACT-050088; HGP-1206; Ro-47-0203; Ro-47-0203/029; Ro-47-0203/039 | Approved | F. Hoffmann-La Roche Ltd | Stayveer, 全可利, Tracleer | United States | Pulmonary Arterial Hypertension | Actelion Pharmaceuticals Ltd | 2001-11-20 | Anemia, Sickle Cell; Chronic thromboembolic pulmonary hypertension; Coronary Vasospasm; Diabetes Mellitus; Diabetes Mellitus, Type 2; Fibrosis; Giant Cell Arteritis; Glaucoma; Heart Defects, Congenital; Heart Septal Defects, Atrial; Hepatopulmonary Syndrome; Hypertension; Hypertension, Pulmonary; Idiopathic Pulmonary Fibrosis; Liver Cirrhosis; Lung Diseases, Interstitial; Persistent Fetal Circulation Syndrome; Pulmonary Arterial Hypertension; Pulmonary Fibrosis; Sarcoidosis; Scleroderma, Systemic; Sleep Apnea Syndromes; Takayasu Arteritis; Ulcer; Vasculitis | Details |
| Macitentan | ACT-064992; Actelion-1; JNJ-67896062 | Approved | Actelion Pharmaceuticals Ltd | Zependo, Opsumit, 傲朴舒 | United States | Pulmonary Arterial Hypertension | Actelion Pharmaceuticals Us Inc | 2013-10-18 | Anemia, Sickle Cell; Angina Pectoris; Chronic Disease; Chronic thromboembolic pulmonary hypertension; Eisenmenger Complex; Glioblastoma; Heart Defects, Congenital; Heart Failure; Heart Failure, Diastolic; Hypertension, Pulmonary; Idiopathic Pulmonary Fibrosis; Pulmonary Arterial Hypertension; Pulmonary Embolism; Scleroderma, Systemic; Scleroderma-associated interstitial lung diseases; Thromboembolism; Ulcer | Details |
| Aprocitentan | ACT-132577; AC-080; JNJ-2820 | Approved | Actelion Pharmaceuticals Ltd, Idorsia Pharmaceuticals Ltd | TRYVIO, JERAYGO | United States | Hypertension | Idorsia Pharmaceuticals Ltd | 2024-03-19 | Essential Hypertension; Hepatic Insufficiency; Hypertension; Renal Insufficiency, Chronic | Details |
- Overview
- Product List
- Marketed Drug Information
- Clinical Drug Information
Share to:
Online Message
Contact Us
[North America]: +1 800-810-0816
[Switzerland]: +41 800 040 012
[Asia & Pacific]: +86 400-682-2521
[North America]: 1 Innovation Way, Newark, DE 19711, USA
[Switzerland]: ACRObiosystems AG, c/o Zug Dammstrasse Centre AG, Dammstrasse 19, 6300 Zug Switzerland