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ENPP3

ENPP3 Overview

English NameEctonucleotide pyrophosphatase/phosphodiesterase family member 3Approved Drugs0
Drugs in Clinical Trials3Target SynonymEC:3.1.4.1，E-NPP 3，PD-Ibeta，NPPase，CD203c，PDNP3，Phosphodiesterase I/nucleotide pyrophosphatase 3，Nucleotide diphosphatase，ENPP3，DJ914N13.3 (Phosphodiesterase I/Nucleotide Pyrophosphatase 3)，Phosphodiesterase-I Beta，Phosphodiesterase I Beta，CD203c Antigen，Gp130RB13-6，NPP3，B10，Ectonucleotide pyrophosphatase/phosphodiesterase family member 3，Ectonucleotide Pyrophosphatase/Phosphodiesterase 3，DJ1005H11.3 (Phosphodiesterase I/Nucleotide Pyrophosphatase 3)，EC:3.6.1.9
Highest Development StagePhase 2 Clinical
English NameEctonucleotide pyrophosphatase/phosphodiesterase family member 3
Target SynonymEC:3.1.4.1，E-NPP 3，PD-Ibeta，NPPase，CD203c，PDNP3，Phosphodiesterase I/nucleotide pyrophosphatase 3，Nucleotide diphosphatase，ENPP3，DJ914N13.3 (Phosphodiesterase I/Nucleotide Pyrophosphatase 3)，Phosphodiesterase-I Beta，Phosphodiesterase I Beta，CD203c Antigen，Gp130RB13-6，NPP3，B10，Ectonucleotide pyrophosphatase/phosphodiesterase family member 3，Ectonucleotide Pyrophosphatase/Phosphodiesterase 3，DJ1005H11.3 (Phosphodiesterase I/Nucleotide Pyrophosphatase 3)，EC:3.6.1.9
Approved Drugs0
Drugs in Clinical Trials3
Highest Development StagePhase 2 Clinical

ENPP3 Product List

  • Product Category

    Protein (6)Cell (1)

  • Product Status

    Launched (7)

  • Species

    Human (5)Mouse (2)

  • Tag

    His Tag (2)His Tag & Avi Tag (1)Fc Tag (2)- (1)Fc Tag & Avi Tag (1)

  • Conjugate

    Unconjugated (4)Biotin-labeled (2)- (1)

Total: 7
  • 1

ENPP3 Background

The human NPP family contains seven members which can be classified into two groups according to their substrate preferences. The first class comprises the nucleotide-degrading proteins NPP1, 3 and 4. NPP3 (CD203c, ENPP3) is expressed in multiple organs, including on epithelial and mucosal surfaces, and notably on basophils and mast cells. Activation of basophils by antigen-bound IgE leads to release of inflammatory mediators and rapid upregulation of NPP3 to the cell surface. This protein is in fact a common marker for diagnosing allergen sensitivity with patient basophils by flow cytometry. Basophils and mast cells mediate the response to certain pathogens, as well as acute and chronic allergic reactions. Following activation, these cells release ATP, which further stimulates them in an autocrine manner. NPP3 upregulation serves to degrade ATP and suppress chronic allergic inflammation (but not the acute response).

ENPP3 Synonyms

ENPP3,CD203c,NPP3,E-NPP3,PD-Ibeta,NPPase,PDNP3
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