Select Language
Free Registration

EphA4

EphA4 Overview

English NameErythropoietin-producing hepatocellular receptor A4Approved Drugs0
Drugs in Clinical Trials3Target SynonymEphrin type-A receptor 4，EPH-like kinase 8 (EK8; hEK8)，Tyrosine-protein kinase TYRO1，Tyrosine-protein kinase receptor SEK，EPH Receptor A4，TYRO1，HEK8，Tyrosine-Protein Kinase Receptor SEK，Tyrosine-Protein Kinase TYRO1，Ephrin Type-A Receptor 4，EPH-Like Kinase 8，EC 2.7.10.1，EK8，SEK，Receptor Protein-Tyrosine Kinase HEK8，TYRO1 Protein Tyrosine Kinase，EC 2.7.10
Highest Development StagePhase 1 Clinical
English NameErythropoietin-producing hepatocellular receptor A4
Target SynonymEphrin type-A receptor 4，EPH-like kinase 8 (EK8; hEK8)，Tyrosine-protein kinase TYRO1，Tyrosine-protein kinase receptor SEK，EPH Receptor A4，TYRO1，HEK8，Tyrosine-Protein Kinase Receptor SEK，Tyrosine-Protein Kinase TYRO1，Ephrin Type-A Receptor 4，EPH-Like Kinase 8，EC 2.7.10.1，EK8，SEK，Receptor Protein-Tyrosine Kinase HEK8，TYRO1 Protein Tyrosine Kinase，EC 2.7.10
Approved Drugs0
Drugs in Clinical Trials3
Highest Development StagePhase 1 Clinical

EphA4 Product List

  • Product Category

    Protein (1)

  • Product Status

    Launched (1)

  • Species

    Human (1)

  • Tag

    His Tag (1)

  • Conjugate

    Unconjugated (1)

Cat. No.SpeciesHostProduct DescriptionStructurePurityFeature
EP4-H52H8
Human
HEK293
Human EphA4 Protein, His Tag
Total: 1
  • 1

EphA4 Background

Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.

EphA4 Synonyms

EphA4,HEK8,SEK,TYRO1,EK8

Clinical Drug Information

English NameResearch CodeHighest Development StageCompanyIndicationClinical Trial
ORT-247ORT247; ORT-247Phase 1 ClinicalOrthogonal Neuroscience IncAmyotrophic Lateral Sclerosis
Details
mEphA4-FcmEphA4-FcPhase 1 ClinicalQueensland Brain InstituteAmyotrophic Lateral Sclerosis; Nerve Degeneration; Nervous System Diseases
Details
E2025E-2025; E2025Phase 1 ClinicalEisai IncAlzheimer Disease
Details
  • Overview
  • Product List
  • Clinical Drug Information
Share to:

Join UsLegalSite MapPrivacy PolicyTerms and Conditions
Website Feedback
Contact Us

[North America]: +1 800-810-0816
[Switzerland]: +41 800 040 012
[Asia & Pacific]: +86 400-682-2521

order@acrobiosystems.com

[North America]: 1 Innovation Way, Newark, DE 19711, USA
[Switzerland]: ACRObiosystems AG, c/o Zug Dammstrasse Centre AG, Dammstrasse 19, 6300 Zug Switzerland