EphA5

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EphA5 Overview

Molecule Name

EPH Receptor A5

Synonyms

Ephrin type-A receptor 5

Drug Development Progress

Drugs in Clinical Trials1

Approved Drugs0

Highest Development StagePhase 2 Clinical

Target Synonym

EPHA5，BSK，EphA5，EC 2.7.10，Receptor Protein-Tyrosine Kinase HEK7，Tyrosine-Protein Kinase Receptor EHK-1，Epididymis Secretory Sperm Binding Protein，EK7，Hek7，EHK-1，EC 2.7.10.1，EPH-like kinase 7，EPH-Like Kinase，EPH homology kinase 1，Brain-Specific Kinase，EPH Homology Kinase，Ephrin type-A receptor 5，Ephrin Type-A Receptor，HEK7，CEK7，EHK1，TYRO4

Background

Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance.