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EphA5

EphA5 Overview

English NameEPH Receptor A5Approved Drugs0
Drugs in Clinical Trials1Target SynonymEPHA5，BSK，EphA5，EC 2.7.10，Receptor Protein-Tyrosine Kinase HEK7，Tyrosine-Protein Kinase Receptor EHK-1，Epididymis Secretory Sperm Binding Protein，EK7，Hek7，EHK-1，EC 2.7.10.1，EPH-like kinase 7，EPH-Like Kinase，EPH homology kinase 1，Brain-Specific Kinase，EPH Homology Kinase，Ephrin type-A receptor 5，Ephrin Type-A Receptor，HEK7，CEK7，EHK1，TYRO4
Highest Development StagePhase 2 Clinical
English NameEPH Receptor A5
Target SynonymEPHA5，BSK，EphA5，EC 2.7.10，Receptor Protein-Tyrosine Kinase HEK7，Tyrosine-Protein Kinase Receptor EHK-1，Epididymis Secretory Sperm Binding Protein，EK7，Hek7，EHK-1，EC 2.7.10.1，EPH-like kinase 7，EPH-Like Kinase，EPH homology kinase 1，Brain-Specific Kinase，EPH Homology Kinase，Ephrin type-A receptor 5，Ephrin Type-A Receptor，HEK7，CEK7，EHK1，TYRO4
Approved Drugs0
Drugs in Clinical Trials1
Highest Development StagePhase 2 Clinical

EphA5 Product List

  • Product Category

    Protein (1)

  • Product Status

    Launched (1)

  • Species

    Human (1)

  • Tag

    His Tag (1)

  • Conjugate

    Unconjugated (1)

Cat. No.SpeciesHostProduct DescriptionStructurePurityFeature
EP5-H52H5
Human
HEK293
Human EphA5 Protein, His Tag (MALS verified)
Total: 1
  • 1

EphA5 Background

Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance.

EphA5 Synonyms

Ephrin type-A receptor 5

Clinical Drug Information

English NameResearch CodeHighest Development StageCompanyIndicationClinical Trial
MBRC-101MBRC-101Phase 2 ClinicalMBrace Therapeutics IncNeoplasms
Details
  • Overview
  • Product List
  • Clinical Drug Information
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