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FGF acidic

FGF acidic Overview

English NameFibroblast growth factor 1Approved Drugs0
Drugs in Clinical Trials2Target SynonymFibroblast Growth Factor 1 (Acidic)，HBGF1，Acidic fibroblast growth factor，Heparin-binding growth factor 1，HBGF-1，Endothelial cell growth factor，FGF1，Fibroblast Growth Factor 1，Endothelial Cell Growth Factor， Alpha，Endothelial Cell Growth Factor， Beta，FGF-1，AFGF，FGFA，ECGF，Beta-Endothelial Cell Growth Factor，ECGF-Beta，FGF-Alpha，GLIO703，ECGFA，ECGFB
Highest Development StagePhase 3 Clinical
English NameFibroblast growth factor 1
Target SynonymFibroblast Growth Factor 1 (Acidic)，HBGF1，Acidic fibroblast growth factor，Heparin-binding growth factor 1，HBGF-1，Endothelial cell growth factor，FGF1，Fibroblast Growth Factor 1，Endothelial Cell Growth Factor， Alpha，Endothelial Cell Growth Factor， Beta，FGF-1，AFGF，FGFA，ECGF，Beta-Endothelial Cell Growth Factor，ECGF-Beta，FGF-Alpha，GLIO703，ECGFA，ECGFB
Approved Drugs0
Drugs in Clinical Trials2
Highest Development StagePhase 3 Clinical

FGF acidic Product List

  • Product Category

    Protein (1)

  • Product Status

    Launched (1)

  • Species

    Human (1)

  • Tag

    Tag Free (1)

  • Conjugate

    Unconjugated (1)

Cat. No.SpeciesHostProduct DescriptionStructurePurityFeature
AFF-H4116
Human
E. coli
Human FGF acidic Protein, Tag Free
Total: 1
  • 1

FGF acidic Background

Heparin-binding growth factor 1 is a protein that in humans is encoded by the FGF1 gene. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF acidic is a potent growth factor for fibroblasts and endothelial cells. FGF acidic is involved in wound repair, angiogenesis, and development. FGF acidic is secreted from cells via an endoplasmic reticulum/Golgi independent mechanism. The ability of FGF acidic to bind to heparin sulfate is required for its ability to interact with FGF receptors and induce signaling. There are four distinct FGF receptors and each has multiple splice variants. FGF acidic binds with high affinity to many, but not all, FGFRs. Signaling cascades activated through FGF basic binding to FGFR include the ras-raf-MAPK, PLCγ/PKC, and PI3K/Akt pathways.

FGF acidic Synonyms

FGF1,AFGF,ECGF,ECGF-beta,ECGFA,ECGFB,FGF-alpha,FGFA,GLIO703,HBGF1

Clinical Drug Information

English NameResearch CodeHighest Development StageCompanyIndicationClinical Trial
Muparfostat sodiumPI-88Phase 3 ClinicalAustralian National UniversityCarcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Liver Neoplasms; Lung Neoplasms; Melanoma; Neoplasms; Prostatic Neoplasms; Skin Melanoma; Solid tumours
Details
TTHX-1114TTHX-1114; NM-141; NM141; TTHX1114Phase 2 ClinicalFlorida State UniversityCorneal Diseases; Corneal Dystrophies, Hereditary; Fuchs' Endothelial Dystrophy; Vascular Diseases
Details
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  • Clinical Drug Information
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