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Frizzled-5

Frizzled-5 Overview

English NameFrizzled-5Approved Drugs0
Drugs in Clinical Trials1Target SynonymFrizzled Class Receptor 5，C2orf31，HFZ5，Frizzled 5， Seven Transmembrane Spanning Receptor，Frizzled Family Receptor 5，Fz-5，FzE5，Seven-Transmembrane Receptor Frizzled-5，Chromosome 2 Open Reading Frame 31，Frizzled (Drosophila) Homolog 5，HFz5
Highest Development StagePhase 1 Clinical
English NameFrizzled-5
Target SynonymFrizzled Class Receptor 5，C2orf31，HFZ5，Frizzled 5， Seven Transmembrane Spanning Receptor，Frizzled Family Receptor 5，Fz-5，FzE5，Seven-Transmembrane Receptor Frizzled-5，Chromosome 2 Open Reading Frame 31，Frizzled (Drosophila) Homolog 5，HFz5
Approved Drugs0
Drugs in Clinical Trials1
Highest Development StagePhase 1 Clinical

Frizzled-5 Product List

  • Product Category

    Protein (1)

  • Product Status

    Launched (1)

  • Species

    Human (1)

  • Tag

    Fc Tag (1)

  • Conjugate

    Unconjugated (1)

Cat. No.SpeciesHostProduct DescriptionStructurePurityFeature
FZ5-H5259
Human
HEK293
Human Frizzled-5 / FZD5 Protein, Fc Tag
Total: 1
  • 1

Frizzled-5 Background

Frizzled-5 (FZD5) is also known as FzE5, which belongs to the G-protein coupled receptor Fz/Smo family. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. FZD5 contains one FZ (frizzled) domain. FZD5 may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. FZD5 interacts specifically with Wnt5A to induce the beta-catenin pathway. FZD5 interacts with GOPC.

Frizzled-5 Synonyms

FZD5,Frizzled-5,C2orf31,,Fz-5,hFz5,FzE5

Clinical Drug Information

English NameResearch CodeHighest Development StageCompanyIndicationClinical Trial
VantictumabOMP-18R5; anti-Fzd7Phase 1 ClinicalBayer AG, Oncomed Pharmaceuticals IncCarcinoma, Non-Small-Cell Lung; Metastatic breast cancer; Osteopetrosis; Pancreatic Neoplasms; Solid tumours
Details
  • Overview
  • Product List
  • Clinical Drug Information
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