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GDF-8

GDF-8 Overview

English NameGrowth/differentiation factor 8Approved Drugs0
Drugs in Clinical Trials8Target SynonymMSTN，GDF-8，GDF8，Growth Differentiation Factor 8，MSLHP，Myostatin，Growth/Differentiation Factor 8
Highest Development StageNDA/BLA
English NameGrowth/differentiation factor 8
Target SynonymMSTN，GDF-8，GDF8，Growth Differentiation Factor 8，MSLHP，Myostatin，Growth/Differentiation Factor 8
Approved Drugs0
Drugs in Clinical Trials8
Highest Development StageNDA/BLA

GDF-8 Product List

  • Product Category

    Protein (10)

  • Product Status

    Launched (10)

  • Species

    Human (5)Human / Mouse / Rat (1)Mouse (2)Cynomolgus (2)

  • Tag

    His Tag (5)Tag Free (1)His Tag & Avi Tag (3)Avi Tag (1)

  • Conjugate

    Unconjugated (5)Biotin-labeled (5)

Cat. No.SpeciesHostProduct DescriptionStructurePurityFeature
HOT
GD8-H5243
Human
HEK293
Human latent GDF-8 Protein, His Tag, low endotoxin (pro & latent) (MALS verified)
HOT
GD8-H5343
Human
CHO
Human latent GDF-8 Protein, His Tag, low endotoxin (MALS verified)
HOT
GD8-H5344
Human / Mouse / Rat
CHO
Human / Mouse / Rat GDF-8 Protein, Tag Free
GD8-H8243
Human
HEK293
Biotinylated Human latent GDF-8 Protein, His Tag, ultra sensitivity (primary amine labeling) (pro & latent) (MALS verified)
GD8-H82Q3
Human
HEK293
Biotinylated Human latent GDF-8 Protein, His,Avitag™ (pro & latent)
GD8-H8313
Human
CHO
Biotinylated Human GDF-8 Protein, Avitag™
GD8-M5243
Mouse
HEK293
Mouse latent GDF-8 Protein, His Tag, low endotoxin
GD8-M82Q3
Mouse
HEK293
Biotinylated Mouse latent GDF-8 Protein, Avitag™,His Tag
GD8-C5243
Cynomolgus
HEK293
Cynomolgus Latent GDF-8 Protein, His Tag, low endotoxin
GD8-C82Q3
Cynomolgus
HEK293
Biotinylated Cynomolgus latent GDF-8 Protein, Avitag™,His Tag
Total: 10
  • 1

GDF-8 Background

Growth differentiation factor 8 (GDF8), also known as myostatin, is a unique member of the transforming growth factor-β superfamily that is expressed in human granulosa cells and has important roles in regulating a variety of ovarian functions. GDF8 acts as a negative regulator of skeletal muscle growth and differentiation. In addition to the expression in the musculoskeletal system, GDF8 is also expressed in various tissues, including the reproductive system.

GDF-8 Synonyms

GDF-8, Myostatin, GDF8, MSTN, Growth,differentiation factor 8

Clinical Drug Information

English NameResearch CodeHighest Development StageCompanyIndicationClinical Trial
Talditercept alfaRO-7239361; BMS-986089; RG-6206; BHV-2000Phase 3 ClinicalBristol-Myers Squibb CompanyMuscular Atrophy, Spinal; Muscular Dystrophy, Duchenne; Neuromuscular Diseases; Obesity; Overweight
Details
EmugrobartGYM-329; RG-6237; RG-70240; RO-7204239Phase 3 ClinicalChugai Pharmaceutical Co LtdDiabetes Mellitus, Type 2; Muscular Atrophy, Spinal; Muscular Dystrophy, Facioscapulohumeral; Obesity; Overweight
Details
TrevogrumabREGN-1033; REGN1033; SAR-391786; GDF8Phase 2 ClinicalRegeneron Pharmaceuticals IncMyositis, Inclusion Body; Obesity; Sarcopenia
Details
AAV1-FS344AAV1-Follistatin; AAV1-FS344Phase 2 ClinicalNationwide Children'S HospitalBecker muscular dystrophy; Muscular Dystrophy, Duchenne; Myositis, Inclusion Body
Details
EL-22EL-22Phase 1 ClinicalObesity
Details
IBIO-600IBIO-600Phase 1 ClinicalAstralBio IncObesity; Overweight
Details
RinvaterceptRKER-065; KER-065Phase 1 ClinicalKeros Therapeutics IncNeuromuscular Diseases; Obesity
Details
SRK-439SRK-439Phase 1 ClinicalScholar Rock IncHeart Diseases; Obesity
Details
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