gH&gL

gH&gL Product List

  • Product Category

    Antibody (1)

  • Product Status

    Launched (1)

  • Species

    Mouse (1)

  • Tag

    - (1)

  • Conjugate

    Unconjugated (1)

Cat. No.SpeciesHostProduct DescriptionStructurePurityFeature
GHL-MY2111
Mouse
HEK293
Monoclonal Anti-VZV gH & gL Antibody, Human IgG1 (4F12) (MALS verified)
Total: 1
  • 1

gH&gL Background

Varicella-zoster virus (VZV) is the alphaherpesvirus that causes chicken pox (varicella) and shingles (zoster). As for all herpesviruses, VZV relies on a fusion complex comprised of three core glycoproteins, gB, gH and gL, required for entry of virions into host cells. VZV ORFs 37 and 60 encode gH (841aa; 118 kDa) and gL (160aa; 20 kDa), respectively, which are N- and O-linked glycosylated and form a heterodimer that is necessary for the activation of gB.

Clinical Drug Information

English NameResearch CodeHighest Development StageCompanyIndicationClinical Trial
XCUR-17XCUR-17Phase 1 ClinicalExicure IncPsoriasis
Details

Marketed Drug Information

English NameResearch CodeHighest Development StageCompanyEarliest Brand NameEarliest Approval CountryEarliest IndicationEarliest Approval CompanyEarliest Approval DateIndicationClinical Trial
BrodalumabIL-17R mAb; MEDI-6365; KHK-4827; AMG-827ApprovedAmgen IncSiliq, Lumicef, Kyntheum, 立美芙JapanPsoriasis; Arthritis, PsoriaticKyowa Kirin Co Ltd2016-07-04Non-radiographic axial spondyloarthritis; Arthritis, Rheumatoid; Spondylitis, Ankylosing; Scleroderma, Systemic; Psoriasis; Asthma; Arthritis, Psoriatic; Hidradenitis Suppurativa; Crohn Disease; Plaque psoriasis
Details
  • Product List
  • Marketed Drug Information
  • Clinical Drug Information
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