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Menu
Home PageAll MoleculesIL-31
IL-31
IL-31 Overview
| English Name | Interleukin-31 | Approved Drugs | 0 |
| Drugs in Clinical Trials | 5 | Target Synonym | Interleukin 31，IL-31 |
| Highest Development Stage | Phase 2 Clinical | ||
| English Name | Interleukin-31 |
| Target Synonym | Interleukin 31，IL-31 |
| Approved Drugs | 0 |
| Drugs in Clinical Trials | 5 |
| Highest Development Stage | Phase 2 Clinical |
IL-31 Product List
- Product Category
Protein (8)Kits (1)
- Product Status
Launched (9)
- Species
Human (4)Cynomolgus (3)Mouse (2)
- Tag
His Tag (4)His Tag & Avi Tag (3)Tag Free (1)- (1)
- Conjugate
Unconjugated (5)Biotin-labeled (3)- (1)
| Cat. No. | Species | Host | Product Description | Structure | Purity | Feature |
|---|---|---|---|---|---|---|
HOT IL1-H5219 |  Human | HEK293 | Human IL-31 Protein, premium grade |  |  |  |
HOT IL1-H5247 | Human | HEK293 | Human IL-31 Protein, His Tag, low Endotoxin (MALS verified) |  | | |
HOT IL1-C5245 |  Cynomolgus | HEK293 | Cynomolgus IL-31 Protein, His Tag, low endotoxin |  | | |
CEA-C243 | Human | - | Human IL-31 ELISA Kit | |||
IL1-H82E6 | Human | HEK293 | Biotinylated Human IL-31 Protein, His,Avitag™ (MALS verified) |  | | |
IL1-M5244 |  Mouse | HEK293 | Mouse IL-31 Protein, His Tag (HPLC verified) |  | | |
IL1-M82Q9 | Mouse | HEK293 | Biotinylated Mouse IL-31 Protein, His,Avitag™ (MALS verified) |  | |  |
IL1-C52H3 | Cynomolgus | HEK293 | Cynomolgus IL-31 Protein, His Tag, low endotoxin (MALS verified) |  | | |
IL1-C82E3 | Cynomolgus | HEK293 | Biotinylated Cynomolgus IL-31 Protein, His,Avitag™ (HPLC verified) |  | | |
Total: 9
- 1
IL-31 Background
IL-31 is an inflammatory cytokine that helps trigger cell-mediated immunity against pathogens. Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. It has also been identified as a major player in a number of chronic inflammatory diseases, including atopic dermatitis. May function in skin immunity. IL-31 is produced by a variety of cells, namely type 2 helper (TH2) T-cells. IL-31 sends signals through a receptor complex made of IL-31RA and oncostatin M receptor β (OSMRβ) expressed in immune and epithelial cells. These signals activate three pathways: ERK1/2 MAP kinase, PI3K/AKT, and JAK1/2 signaling pathways.
IL-31 Synonyms
IL-31,IL31,Interleukin-31
Clinical Drug Information
| English Name | Research Code | Highest Development Stage | Company | Indication | Clinical Trial |
|---|---|---|---|---|---|
| JNJ-5939 | JNJ-5939; NM-26; NM26-2198; JNJ-95475939 | Phase 2 Clinical | Numab Therapeutics Ag | Dermatitis, Atopic; Inflammation | Details |
| ATTO-3712 | ATTO-3712 | Phase 1 Clinical | Attovia Therapeutics Inc | Dermatitis, Atopic; Pruritus | Details |
| BBT-001 | BBT001; BBT-001 | Phase 1 Clinical | Bambusa Therapeutics Inc | Dermatitis, Atopic | Details |
| ZL-1503 | ZL-1503 | Phase 1 Clinical | Zai Lab Ltd | Dermatitis, Atopic | Details |
| ATTO-1310 | ATTO-1310 | Phase 1 Clinical | Attovia Therapeutics Inc | Dermatitis, Atopic; Pruritus | Details |
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