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IL-5 R alpha

IL-5 R alpha

IL-5 R alpha Overview

Molecule Name
Interleukin-5 receptor subunit alpha
Synonyms
IL5Ra,CD125
Drug Development Progress
Drugs in Clinical Trials2
Approved Drugs1
Highest Development StageApproved
Target Synonym
Interleukin 5 Receptor， Alpha，Interleukin-5 Receptor Subunit Alpha，HSIL5R3，Interleukin-5 Receptor Alpha Chain，CDw125，Interleukin-5 Receptor alpha Subunit，Interleukin 5 Receptor Type 3，CD125 Antigen，Interleukin 5 Receptor Subunit Alpha，IL-5 Receptor Subunit Alpha，IL-5R-Alpha，IL5R，IL5RA，CD125，IL-5RA，IL-5R Subunit Alpha
Background
Interleukin-5 receptor subunit alpha (IL5RA) is also known as IL-5 receptor subunit alpha, IL-5R subunit alpha and CD125,which is a single-pass type I membrane protein that belongs to the type I cytokine receptor family and type 5 subfamily.IL5R, a heterodimer of an alpha and a beta subunit, is expressed on eosinophils and basophils. IL5RA / CD125 is the receptor for interleukin-5 (IL5) and the alpha chain can bind to IL5. The WSXWS motif of IL5RA appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.The beta subunit of IL5R is common to the IL3, IL5 and GM-CSF receptors.

IL-5 R alpha Product List

Species
  • Human（3）
  • Mouse（1）
Tag
  • His Tag（2）
  • Fc Tag（1）
  • Fc Tag & Avi Tag（1）
Host
  • HEK293（4）
Conjugate
  • Unconjugated（3）
  • Biotin-labeled（1）
Grade
  • RUO（4）
Low Endotoxin
  • Yes（1）
  • No（3）
MoleculeCat. No.Product NameSpeciesHostStructurePurityActivitySize&Price
IL-5 R alpha
ILA-H5269
Human IL-5 R alpha / CD125 Protein, Fc Tag (MALS verified)
Human
HEK293
MALSSDS-PAGE
ELISA

$410.00

100ug
IL-5 R alpha
AIDD‑Ready
ILA-H52H4
Human IL-5 R alpha / CD125 Protein, His Tag, low endotoxin (MALS & BLI verified)
Human
HEK293
MALSSDS-PAGE
BLI

$325.00

50ug
IL-5 R alpha
Avitag
ILA-H82F5
Biotinylated Human IL-5 R alpha / CD125 Protein, Avitag™,Fc Tag (MALS verified)
Human
HEK293
MALSSDS-PAGE
ELISA

$360.00

25ug
IL-5 R alpha
AIDD‑Ready
ILA-M52H7
Mouse IL-5 R alpha / CD125 Protein, His Tag (MALS & SPR verified)
Mouse
HEK293
MALSSDS-PAGE
SPR

$350.00

100ug
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Clinical Drug Information

English NameResearch CodeHighest Development StageCompanyIndicationClinical Trial
IL-5 CAR-T Cell Therapy (Zhejiang University)Phase 1 ClinicalZhejiang University
Hematologic Diseases; Neoplasms
Details
TrabikibartCSL-311Phase 1 ClinicalCsl Ltd
Asthma
Details

Marketed Drug Information

English NameResearch CodeHighest Development StageCompanyFirst Brand NameFirst Approved CountryFirst IndicationFirst Approved CompanyFirst Approved DateIndicationClinical Trial
BenralizumabKHK-4563; MEDI-563; BIW-8405; BIW-8405-IL-5RApprovedBiowa Inc, Medimmune LlcFasenra, 凡舒卓United StatesAsthmaAstrazeneca Ab2017-11-14
Asthma; Asthma, Exercise-Induced; Bronchiectasis; Chronic Urticaria; Dermatitis; Dermatitis, Atopic; Drug Hypersensitivity Syndrome; Eczema; Eosinophilia; Eosinophilic Asthma; Eosinophilic Esophagitis; Eosinophilic gastroenteritis (EG); Eosinophilic Granulomatosis With Polyangiitis; Gastroenteritis; Genetic Diseases, Inborn; Granulomatosis with Polyangiitis; Hematologic Diseases; Hypereosinophilic Syndrome; Hypersensitivity; Hypersensitivity, Immediate; Immune System Diseases; Leukocyte Disorders; Nasal Polyps; Pemphigoid, Bullous; Pulmonary Disease, Chronic Obstructive; Respiratory Tract Diseases; Sinusitis; Skin Diseases; Skin Diseases, Eczematous; Skin Diseases, Genetic
Details
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