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Integrin alpha 4 beta 7

Integrin alpha 4 beta 7 Overview

English NameIntegrin alpha-4/beta-7Approved Drugs4
Drugs in Clinical Trials12Target SynonymLPAM-1，Lymphocyte Peyer's patch Adhesion Molecule 1
Highest Development StageApproved
English NameIntegrin alpha-4/beta-7
Target SynonymLPAM-1，Lymphocyte Peyer's patch Adhesion Molecule 1
Approved Drugs4
Drugs in Clinical Trials12
Highest Development StageApproved

Integrin alpha 4 beta 7 Product List

  • Product Category

    Protein (3)Kits (1)Cell (1)

  • Product Status

    Launched (5)

  • Species

    Human (4)Cynomolgus (1)

  • Tag

    His Tag (3)- (2)

  • Conjugate

    Unconjugated (3)- (2)

Total: 5
  • 1

Integrin alpha 4 beta 7 Background

Integrin alpha 4 beta 7 is an integrin family adhesion receptor that shares subunits with alpha 4 beta 1 (VLA4) and the E-Cadherin receptor, alpha E beta 7 . Integrin alpha 4 beta 7, which is critical for homing to intestinal mucosa, is induced during T cell activation in Peyer’s patches or mesenteric lymph nodes.Its expression requires signals from local dendritic and stromal cells, including secreted retinoic acid. The HIV-1 envelope protein gp120 binds to the active form of Integrin alpha 4 beta 7, and this may or may not account for the concentration of HIV-1 virus in the gut-associated lymphoid tissue (GALT). Integrin alpha 4 beta 7 may also be involved in lymphocyte trafficking in acute intestinal graft vs. host disease (GVHD).

Integrin alpha 4 beta 7 Synonyms

Integrin alpha 4 beta 7,ITGA4&ITGB7
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  • Product List