JAK1

JAK1 Overview

English NameTyrosine-protein kinase JAK1Approved Drugs13
Drugs in Clinical Trials46Target SynonymJAK1B,Tyrosine-protein kinase JAK1,JAK1,Janus Kinase 1,JAK1A,EC 2.7.10.2,JAK-1,JTK3,EC:2.7.10.2,EC 2.7.10
Highest Development StageApproved
English NameTyrosine-protein kinase JAK1
Target SynonymJAK1B,Tyrosine-protein kinase JAK1,JAK1,Janus Kinase 1,JAK1A,EC 2.7.10.2,JAK-1,JTK3,EC:2.7.10.2,EC 2.7.10
Approved Drugs13
Drugs in Clinical Trials46
Highest Development StageApproved

JAK1 Product List

  • Product Category

    Protein (1)

  • Product Status

    Launched (1)

  • Species

    Human (1)

  • Tag

    His Tag (1)

  • Conjugate

    Unconjugated (1)

Cat. No.SpeciesHostProduct DescriptionStructurePurityFeature
JA1-H5547
Human
InsectCells
Human JAK1 Protein, His Tag
Total: 1
  • 1

JAK1 Background

JAK1 is a human tyrosine kinase protein essential for signaling for certain type I and type II cytokines. It interacts with the common gamma chain (γc) of type I cytokine receptors, to elicit signals from the IL-2 receptor family (e.g. IL-2R, IL-7R, IL-9R and IL-15R), the IL-4 receptor family (e.g. IL-4R and IL-13R), the gp130 receptor family (e.g. IL-6R, IL-11R, LIF-R, OSM-R, cardiotrophin-1 receptor (CT-1R), ciliary neurotrophic factor receptor (CNTF-R), neurotrophin-1 receptor (NNT-1R) and Leptin-R). Jak1 plays a critical role in initiating responses to multiple major cytokine receptor families. Expression of JAK1 in cancer cells enables individual cells to contract, potentially allowing them to escape their tumor and metastasize to other parts of the body

JAK1 Synonyms

JAK1,JAK-1,JAK1A,JAK1B,Jak1

Clinical Drug Information

English NameResearch CodeHighest Development StageCompanyIndicationClinical Trial
PovorcitinibINCB54707; INCB-54707; INCB054707; INCB-054707Phase 3 ClinicalIncyte CorpAngioedema; Asthma; Chronic Urticaria; Hidradenitis Suppurativa; Kidney Diseases; Prurigo Nodularis; Pruritus; Renal Insufficiency; Urticaria; Vitiligo
Details
WXFL-10203614WXFL-10203614Phase 3 ClinicalWuxi Apptec Co Ltd, Wuxi Fuxin Pharmaceutical Research And Development Co LtdArthritis, Rheumatoid; Colitis, Ulcerative; Crohn Disease; Dermatitis, Atopic
Details
TLL-018TLL-018Phase 3 ClinicalTll Pharmaceutical LlcArthritis, Rheumatoid; Chronic Urticaria; Colitis, Ulcerative; Dermatitis, Atopic; Lupus Erythematosus, Systemic; Plaque psoriasis; Psoriasis; Urticaria
Details
PumecitinibPG-011Phase 3 ClinicalPrime Gene Therapeutics Co LtdRhinitis, Allergic; Rhinitis, Allergic, Seasonal
Details
Ruxolitinib (Taro Pharmaceuticals)Phase 3 ClinicalTaro Pharmaceuticals Usa IncDermatitis, Atopic; Hidradenitis Suppurativa
Details
Ruxolitinib Gel(Hangzhou Zhongmei Huadong)HDM3010; HDM-3010Phase 3 ClinicalHangzhou Zhongmei Huadong Pharmaceutical Co LtdPrurigo Nodularis; Vitiligo
Details
BHV-8000TLL-041; TLL041Phase 3 ClinicalHangzhou Highlightll Pharmaceutical Co LtdAlzheimer Disease; Amyotrophic Lateral Sclerosis; Central Nervous System Diseases; Parkinson Disease
Details
LW-402LW-402Phase 3 ClinicalShanghai Longwood Biopharmaceuticals Co LtdArthritis, Rheumatoid; Dermatitis, Atopic; Inflammatory Bowel Diseases; Spondylitis, Ankylosing; Vitiligo
Details
VVN-461VVN461LD; VVN-461; VVN461e; VVN-461-ePhase 3 ClinicalVivaVision Biotech IncDry Eye Syndromes; Inflammation; Postoperative inflammation; Uveitis; Uveitis, Anterior
Details
QuecitinibQY201; QY-201Phase 3 ClinicalE-nitiate Biopharmaceuticals (Hangzhou) Co LtdAlopecia Areata; Arthritis, Rheumatoid; Dermatitis, Atopic; Prurigo; Prurigo Nodularis; Psoriasis; Spondylitis, Ankylosing; Vitiligo
Details
VC-005VC-005Phase 3 ClinicalJiangsu Vcare Pharmatech Co LtdAlopecia Areata; Arthritis, Rheumatoid; Colitis, Ulcerative; Crohn Disease; Dermatitis, Atopic; Eczema; Inflammatory Bowel Diseases; Joint Diseases; Spondylitis, Ankylosing; Vitiligo
Details
ZemprocitinibLNK01001; LNK-001; LNK001; LNK-207; EQ-121; LNK-01001Phase 3 ClinicalLynk Pharmaceutical (Hangzhou) Co LtdArthritis, Rheumatoid; Dermatitis, Atopic; Spondylitis, Ankylosing
Details
WXSH-0150WXSH-0150; TUL-01101Phase 2 ClinicalZhuhai United Laboratories Co LtdArthritis, Rheumatoid; Dermatitis, Atopic
Details
NS-229NS-229Phase 2 ClinicalNeurosearch AsEosinophilic Granulomatosis With Polyangiitis; Epilepsy
Details
Ivarmacitinib sulfate Base gel(Jiangsu Hengrui Medicine)SHR0302 basePhase 2 ClinicalJiangsu Hengrui Medicine Co LtdVitiligo
Details
Tofacitinib citrate (CAGE Bio)CGB-500; CGB-501Phase 2 ClinicalCAGE Bio IncAlopecia Areata; Dermatitis, Atopic
Details
ALY-101ALY-101Phase 2 ClinicalAlys Pharmaceuticals IncAlopecia Areata; Dermatitis, Atopic; Eczema
Details
TDM-180935TDM-180935Phase 2 ClinicalJiaxing TechnoDerma Medicines IncDermatitis, Atopic
Details
AC-201AC-201Phase 2 ClinicalAccro Bioscience (Suzhou) Co LtdLupus Erythematosus, Systemic; Plaque psoriasis; Psoriasis; Uveitis
Details
H-018H018; H-018Phase 2 ClinicalJiangsu Carephar Pharmaceutical Co Ltd, Nanjing Shenzhou Jiamei Pharmaceutical Co LtdArthritis, Rheumatoid; Dermatitis, Atopic; Vitiligo
Details
Fingolimod/TofacitinibFMX-114Phase 2 ClinicalVyne Therapeutics IncDermatitis, Atopic
Details
JYP-0061JYP-0061Phase 2 ClinicalGuangzhou Jiayue Pharmaceutical Technology Co LtdAlopecia Areata; Arthritis, Rheumatoid; Autoimmune Diseases; Demyelinating Diseases; Dermatitis, Atopic; Neuromyelitis Optica; Prurigo Nodularis; Spondylarthritis; Vitiligo
Details
Londamocitinib XinafoateAZD-4604Phase 2 ClinicalAstrazeneca PlcAsthma
Details
LepzacitinibPhase 2 ClinicalAclaris Therapeutics IncDermatitis, Atopic
Details
LNK-01002LNK01002; LNK-1000318Phase 2 ClinicalLynk Pharmaceutical (Hangzhou) Co LtdHematologic Neoplasms; Leukemia, Myeloid, Acute; Myeloproliferative Disorders; Polycythemia Vera; Primary Myelofibrosis; Thrombocythemia, Essential
Details
ItacitinibINCB-039110-adipate; INCB-39110; INCB-039110; IBI-377Phase 2 ClinicalIncyte CorpArthritis, Rheumatoid; Asthma; Bone Marrow Neoplasms; Breast Neoplasms; Bronchiolitis Obliterans; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Chondrosarcoma; Colitis, Ulcerative; Colorectal Neoplasms; Cytokine Release Syndrome; Endometrial Neoplasms; Graft vs Host Disease; Head and Neck Neoplasms; Hematologic Neoplasms; Hemic and Lymphatic Diseases; Hodgkin Disease; Leiomyosarcoma; Leukemia; Leukemia, B-Cell; Leukemia, Myelogenous, Chronic; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Leukemia, Plasma Cell; Leukemia, Prolymphocytic, T-Cell; Liposarcoma; Liposarcoma, Myxoid; Lung Neoplasms; Lymphoma; Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Melanoma; Multiple Myeloma; Myelodysplastic Syndromes; Myelodysplastic-Myeloproliferative Diseases; Myeloproliferative Disorders; Neoplasm Metastasis; Neoplasms; Pancreatic Neoplasms; Plaque psoriasis; Polycythemia Vera; Precursor Cell Lymphoblastic Leukemia-
Details
Elsubrutinib/UpadacitinibABBV-599Phase 1 ClinicalAbbvie IncArthritis, Rheumatoid; Lupus Erythematosus, Systemic
Details
CS-12192CS12192Phase 1 ClinicalShenzhen Chipscreen Biosciences Co LtdAlopecia Areata; Autoimmune Diseases; Dermatitis, Atopic; Enteritis; Graft vs Host Disease; Lupus Erythematosus, Systemic; Multiple Sclerosis
Details
FZJ-003FZJ-003Phase 1 ClinicalShanghai Fudan-Zhangjiang Bio-Pharmaceutical Co LtdArthritis, Rheumatoid; Dermatitis, Atopic
Details
FrevecitinibVR-588; KN-002; KN-002 (Kinaset Therapeutics/Vectura)Phase 1 ClinicalVectura LtdAsthma; Pulmonary Disease, Chronic Obstructive
Details
GLPG-3121GLPG-3121Phase 1 ClinicalGalapagos Nv
Details
tofacitinib (3S Bio)SSS-32Phase 1 Clinical3sbio IncArthritis, Rheumatoid
Details
LP-0184LP-0184Phase 1 ClinicalLeo Pharma A/SDermatitis, Atopic
Details
Tofacitinib(Biora Therapeutics)BT-600; PGN-600Phase 1 ClinicalProgenity IncColitis, Ulcerative
Details
HHT-109HHT-109Phase 1 ClinicalZhejiang Huahai Pharmaceutical Co LtdArthritis, Rheumatoid
Details
Tofacitinib Citrate Modified-Release Tablets(Taizhou Overseas Pharma)Phase 1 ClinicalTaizhou Overseas Pharmaceuticals Co LtdArthritis, Rheumatoid
Details
Abrocitinib Oral Suspension(Pfizer)Phase 1 ClinicalPfizer IncDermatitis, Atopic
Details
Tofacitinib citrate (TWi Biotechnology)IMG 003; AC-1101Phase 1 ClinicalTwi Biotechnology IncGranuloma Annulare
Details
Tofacitinib controlled release (Triastek)T-21; T21; T-19Phase 1 ClinicalTriastek IncArthritis, Rheumatoid
Details
GDC-0214RG-6151; GDC-0214Phase 1 ClinicalGenentech IncAsthma
Details
QY-211QY211; QY-211Phase 1 ClinicalE-nitiate Biopharmaceuticals (Hangzhou) Co LtdDermatitis, Atopic; Eczema; Vitiligo
Details
AQ-280AQ-280Phase 1 ClinicalAqilion ABEosinophilic Esophagitis
Details
PG-018PG-018Phase 1 ClinicalPrime Gene Therapeutics Co LtdGlomerulonephritis, Membranous; Nephrosis
Details
TT-00420/AtezolizumabPhase 1 ClinicalTransThera Sciences (Nanjing) IncGastrointestinal Neoplasms
Details
LBG-1600MPhase 1 ClinicalSuzhou Longbotai Pharmaceutical Co LtdDermatitis, Atopic
Details
NIP-046NIP-046Phase 1 ClinicalNational Institutes Of Pharmaceutical Research And Development Co LtdArthritis, Rheumatoid; Chronic Urticaria
Details

Marketed Drug Information

English NameResearch CodeHighest Development StageCompanyEarliest Brand NameEarliest Approval CountryEarliest IndicationEarliest Approval CompanyEarliest Approval DateIndicationClinical Trial
Filgotinib MaleateG-146034; GLPG-0634; G-146034-101; GS-6034ApprovedGalapagos NvJyselecaEUArthritis, RheumatoidGalapagos Nv2020-09-24Arthritis, Juvenile; Arthritis, Psoriatic; Arthritis, Rheumatoid; Axial Spondyloarthritis; Behcet Syndrome; Colitis, Ulcerative; Crohn Disease; Glomerulonephritis, Membranous; Immunoglobulin G4-Related Disease; Inflammatory Bowel Diseases; Lupus Erythematosus, Cutaneous; Lupus Nephritis; Myositis; Renal Insufficiency; Sjogren's Syndrome; Spondylitis, Ankylosing; Uveitis
Details
Deuterated ruxolitinibCTP-543; C-21543 phosphate; CTP-543 phosphateApprovedConcert Pharmaceuticals IncLEQSELVIUnited StatesAlopecia AreataSun Pharmaceutical Industries Ltd2024-07-25Alopecia Areata; Hepatic Insufficiency; Renal Insufficiency
Details
PeficitinibASP-015K; JNJ-54781532ApprovedAstellas Pharma IncSmyraf, 施觅福JapanArthritis, RheumatoidAstellas Pharma Inc2019-03-29Arthritis, Rheumatoid; Colitis, Ulcerative; Psoriasis
Details
Momelotinib DihydrochlorideCYT-387; GS-0387; GSK-3070785ApprovedCytopia Pty Ltd, Gilead Sciences IncOjjaara, OmjjaraUnited StatesPrimary Myelofibrosis; AnemiaGlaxosmithkline Llc, Glaxosmithkline Plc2023-09-15Anemia; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Myelodysplastic Syndromes; Myeloproliferative Disorders; Neoplasms; Pancreatic Intraductal Neoplasms; Polycythemia Vera; Primary Myelofibrosis; Splenomegaly; Thrombocythemia, Essential; VEXAS Syndome
Details
Ivarmacitinib sulfateSHR-0302; ARQ-252; ARQ-255ApprovedJiangsu Hengrui Medicine Co Ltd艾速达Mainland ChinaSpondylitis, AnkylosingJiangsu Hengrui Medicine Co Ltd2025-03-18Alopecia Areata; Arthritis, Psoriatic; Arthritis, Rheumatoid; Autoimmune Diseases; Colitis, Ulcerative; Crohn Disease; Dermatitis, Atopic; Eczema; Graft vs Host Disease; Hepatic Insufficiency; Lupus Erythematosus, Systemic; Lymphoma, T-Cell, Peripheral; Metastatic breast cancer; Non-radiographic axial spondyloarthritis; Sedation; Solid tumours; Spondylarthritis; Spondylitis, Ankylosing; Triple Negative Breast Neoplasms; Vitiligo
Details
Gecacitinib HydrochlorideZG-0128; ZG-0163ApprovedSuzhou Zelgen Biosciences Co Ltd泽普平Mainland ChinaPrimary MyelofibrosisSuzhou Zelgen Biopharmaceuticals Co Ltd2025-05-27Alopecia Areata; Carcinoma, Non-Small-Cell Lung; Coronavirus Disease 2019 (COVID-19); Dermatitis, Atopic; Graft vs Host Disease; Hepatic Insufficiency; Idiopathic Pulmonary Fibrosis; Lupus Erythematosus, Systemic; Lymphoma; Myelodysplastic Syndromes; Myeloproliferative Disorders; Plaque psoriasis; Pneumonia; Polycythemia Vera; Primary Myelofibrosis; Solid tumours; Spondylitis, Ankylosing; Thrombocythemia, Essential; Vitiligo
Details
AbrocitinibPF-4965842; PF-04965842ApprovedPfizer IncCibinqo, CIBINQO, 希必可United KingdomDermatitis, AtopicPfizer Inc2021-09-09Alopecia Areata; Dermatitis; Dermatitis, Atopic; Eczema; Fatigue; Food Hypersensitivity; Genetic Diseases, Inborn; Granuloma Annulare; Hepatic Insufficiency; Hypersensitivity; Hypersensitivity, Immediate; Immune System Diseases; Plaque psoriasis; Post-Acute COVID-19 Syndrome; Prurigo; Prurigo Nodularis; Pruritus; Renal Insufficiency; Sarcoidosis; Skin Diseases; Skin Diseases, Eczematous; Skin Diseases, Genetic
Details
Tofacitinib CitrateCP-690550-10; CKD-374; Tasocitinib; CP-690550; AC-1101; IMG 003ApprovedPfizer IncJakvinus, Xeljanz, 尚杰United StatesArthritis, RheumatoidPf Prism Cv2012-11-06Alopecia; Alopecia Areata; Amyotrophic Lateral Sclerosis; Arthritis, Juvenile; Arthritis, Psoriatic; Arthritis, Rheumatoid; Axial Spondyloarthritis; Colitis, Ulcerative; Coronavirus Disease 2019 (COVID-19); Crohn Disease; Depression; Dermatitis; Dermatitis, Atopic; Dermatomyositis; Down Syndrome; Dry Eye Syndromes; Eczema; Gastrointestinal Diseases; Glioblastoma; Granuloma Annulare; Granulomatous Disease, Chronic; Hepatic Insufficiency; Hidradenitis Suppurativa; Inflammation; Keratoconjunctivitis Sicca; Kidney Failure, Chronic; Lung Diseases, Interstitial; Lupus Erythematosus, Cutaneous; Lupus Erythematosus, Discoid; Lupus Erythematosus, Systemic; Lymphoma, T-Cell, Cutaneous; Plaque psoriasis; Pneumonia; Psoriasis; Rejection of renal transplantation; Renal Insufficiency; Sacroiliitis; Sarcoidosis; Sarcoidosis, Pulmonary; Scleritis; Scleroderma, Systemic; Sjogren's Syndrome; Spondylitis; Spondylitis, Ankylosing; Uveitis; Vitiligo
Details
GolidocitinibNC-0322; AZD-4205; DZD-4205ApprovedAstrazeneca Plc, Dizal (Jiangsu) Pharmaceutical Co Ltd高瑞哲Mainland ChinaLymphoma, T-Cell, PeripheralDizal (Jiangsu) Pharmaceutical Co Ltd2024-06-18Anemia, Aplastic; Carcinoma, Non-Small-Cell Lung; Epstein-Barr Virus Infections; Hematologic Diseases; Histiocytosis; Lung Neoplasms; Lymphohistiocytosis, Hemophagocytic; Lymphoma, Extranodal NK-T-Cell; Lymphoma, T-Cell; Lymphoma, T-Cell, Cutaneous; Lymphoma, T-Cell, Peripheral; Small Cell Lung Carcinoma; Virus Diseases
Details
Upadacitinib Oral Solution(艾伯维)ApprovedAbbvie IncRINVOQ® LQ, RINVOQ LQ, Rinvoq LqUnited StatesDermatitis, Atopic; Arthritis, Rheumatoid; Spondylitis, Ankylosing; Crohn Disease; Colitis, Ulcerative; Non-radiographic axial spondyloarthritis; Polyarticular Juvenile Idiopathic Arthritis; Arthritis, PsoriaticAbbvie Inc2024-04-26Arthritis, Juvenile; Arthritis, Psoriatic; Arthritis, Rheumatoid; Colitis, Ulcerative; Crohn Disease; Dermatitis, Atopic; Non-radiographic axial spondyloarthritis; Polyarticular Juvenile Idiopathic Arthritis; Spondylitis, Ankylosing
Details
UpadacitinibABT-494ApprovedAbbott LaboratoriesRinvoq, Rinvoq Lq, RINVOQ LQ, 瑞福United StatesArthritis, RheumatoidAbbvie Inc2019-08-16Alopecia Areata; Arthritis, Juvenile; Arthritis, Psoriatic; Arthritis, Rheumatoid; Behcet Syndrome; Blepharitis; Colitis, Ulcerative; Crohn Disease; Dermatitis, Atopic; Giant Cell Arteritis; Hidradenitis Suppurativa; Lung Diseases, Interstitial; Lupus Erythematosus, Systemic; Non-radiographic axial spondyloarthritis; Sleep Wake Disorders; Spondylarthritis; Spondylitis, Ankylosing; Takayasu Arteritis; Vitiligo
Details
BaricitinibLY-3009104; INCB-028050ApprovedIncyte Corp艾乐明, OlumiantEUArthritis, RheumatoidEli Lilly Nederland BV2017-02-13Acute Lung Injury; Aicardi Goutieres syndrome; Alopecia Areata; Anhedonia; Arthritis, Juvenile; Arthritis, Rheumatoid; Cerebral Hemorrhage; Cholangitis, Sclerosing; Conjunctivitis; Coronavirus Disease 2019 (COVID-19); Coronavirus Infections; Depression; Depressive Disorder, Major; Dermatitis, Atopic; Dermatomyositis; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Graft vs Host Disease; Hepatic Insufficiency; HIV Infections; Infections; Job Syndrome; Lichen Planus; Lichen Planus, Oral; Liver Diseases; Lupus Erythematosus, Systemic; Lupus Nephritis; Lupus Vulgaris; Malignant Atrophic Papulosis; Myositis; Nephritis; Pemphigoid, Benign Mucous Membrane; Polymyalgia Rheumatica; Post-Acute COVID-19 Syndrome; Psoriasis; Pyoderma; Pyoderma Gangrenosum; Renal Insufficiency, Chronic; Sarcoidosis; Scleroderma, Diffuse; Severe Acute Respiratory Syndrome; Skin Diseases; Skin Diseases, Papulosquamous; Skin Ulcer; Vitiligo; Wounds and Injuries
Details
Ruxolitinib PhosphateINCB-18424; RUX; INCB 018424 phosphate; INCB-018424; INC-424; INCB-424ApprovedIncyte CorpOPZELURA, Jakavi, JakafiUnited StatesPrimary MyelofibrosisIncyte Corp2011-11-16Alopecia Areata; Anemia, Aplastic; Anemia, Sickle Cell; Arthritis, Rheumatoid; Autoimmune Lymphoproliferative Syndrome; beta-Thalassemia; Bone Marrow Neoplasms; Breast Carcinoma In Situ; Breast Neoplasms; Cachexia; Carcinoma, Intraductal, Noninfiltrating; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Castleman Disease; Chronic eosinophilic leukemia (CEL); Coronavirus Disease 2019 (COVID-19); Coronavirus Infections; Cytokine Release Syndrome; Dermatitis; Dermatitis, Atopic; Eczema; Eosinophilia; Exanthema; Graft vs Host Disease; Hematologic Neoplasms; Hematopoietic stem cell transplantation (HSCT); Hepatomegaly; Hidradenitis Suppurativa; HIV Infections; Hodgkin Disease; Hypereosinophilic Syndrome; Hyperplasia; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myelogenous, Chronic; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative; Leukemia, Myeloid, Chronic-Phase; Leukemia, Myelomonocytic, Chronic; Leukemia, Neutrophilic, Chronic; Leukemia
Details
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