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LGR5

LGR5 Overview

English NameLeucine-rich repeat-containing G-protein coupled receptor 5Approved Drugs0
Drugs in Clinical Trials2Target SynonymFEX，G Protein-Coupled Receptor 49，GRP49，HG38，G-protein coupled receptor HG38，GPR49，GPR67，G-protein coupled receptor 49，Leucine-rich repeat-containing G-protein coupled receptor 5，LGR5，Leucine Rich Repeat Containing G Protein-Coupled Receptor 5，G-Protein Coupled Receptor 67，Orphan G Protein-Coupled Receptor HG38
Highest Development StagePhase 2 Clinical
English NameLeucine-rich repeat-containing G-protein coupled receptor 5
Target SynonymFEX，G Protein-Coupled Receptor 49，GRP49，HG38，G-protein coupled receptor HG38，GPR49，GPR67，G-protein coupled receptor 49，Leucine-rich repeat-containing G-protein coupled receptor 5，LGR5，Leucine Rich Repeat Containing G Protein-Coupled Receptor 5，G-Protein Coupled Receptor 67，Orphan G Protein-Coupled Receptor HG38
Approved Drugs0
Drugs in Clinical Trials2
Highest Development StagePhase 2 Clinical

LGR5 Product List

  • Product Category

    Protein (4)Cell (1)

  • Product Status

    Launched (5)

  • Species

    Human (4)Cynomolgus (1)

  • Tag

    His Tag (2)Fc Tag (1)His Tag & Avi Tag (1)- (1)

  • Conjugate

    Unconjugated (3)Biotin-labeled (1)- (1)

Cat. No.SpeciesHostProduct DescriptionStructurePurityFeatureOrder Now
CHEK-ATP327
Human
HEK293
HEK293/Human LGR5 Stable Cell Line Add to Cart
LG5-H5253
Human
HEK293
Human LGR5 / GPR49 protein, Fc Tag
 Add to Cart
LG5-H52H3
Human
HEK293
Human LGR5 / GPR49 Protein, His Tag, low endotoxin
 Add to Cart
LG5-H82E4
Human
HEK293
Biotinylated Human LGR5 / GPR49 (22-561) Protein, His,Avitag™
 Add to Cart
LG5-C52H7
Cynomolgus
HEK293
Cynomolgus LGR5 / GPR49 protein, His Tag
 Add to Cart
Total: 5
  • 1

LGR5 Background

LGR5 (also known as GPR49) is a seven-transmembrane protein of the class A Rhodopsin-like family of GPCRs. LGR5 and LGR4 bind the R-spondins with high affinity and mediate the potentiation of Wnt/β-catenin signaling by enhancing Wnt-induced LRP6 phosphorylation. The LGR5/RSPO complex could promote Wnt signalling via the neutralization of two transmembrane E3 ligases, RNF43 and ZNRF3.

LGR5 Synonyms

LGR5, GPR49, GPR67, G-protein coupled receptor 49, G-protein coupled receptor 67, G-protein coupled receptor HG38, Leucine-rich repeat-containing G-protein coupled receptor 5

Clinical Drug Information

English NameResearch CodeHighest Development StageCompanyIndicationClinical Trial
PetosemtamabMCLA-158Phase 2 ClinicalMerus NvCarcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Esophageal Neoplasms; Gastroesophageal Junction Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms
Details
CNA-3103CNA-3103Phase 2 ClinicalCarina Biotech Pty LtdColorectal Neoplasms
Details
  • Overview
  • Product List
  • Clinical Drug Information
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