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Home PageAll MoleculesLTBR
LTBR
LTBR Overview
| English Name | Tumor necrosis factor receptor superfamily member 3 | Approved Drugs | 0 |
| Drugs in Clinical Trials | 1 | Target Synonym | Lymphotoxin-beta receptor，Tumor necrosis factor receptor type III，LTBR，Tumor necrosis factor receptor superfamily member 3，D12S370，TNFRSF3，TNFCR，TNFR3，TNFR Superfamily， Member 3，Lymphotoxin B Receptor，LT-BETA-R，TNF-R-III，TNFR2-RP，TNF-RIII，TNFR-III，TNFR-RP，Lymphotoxin beta Receptor，Tumor necrosis factor C receptor，Tumor Necrosis Factor Receptor 2-Related Protein，Lymphotoxin Beta Receptor (TNFR Superfamily， Member 3) |
| Highest Development Stage | Phase 1 Clinical | ||
| English Name | Tumor necrosis factor receptor superfamily member 3 |
| Target Synonym | Lymphotoxin-beta receptor，Tumor necrosis factor receptor type III，LTBR，Tumor necrosis factor receptor superfamily member 3，D12S370，TNFRSF3，TNFCR，TNFR3，TNFR Superfamily， Member 3，Lymphotoxin B Receptor，LT-BETA-R，TNF-R-III，TNFR2-RP，TNF-RIII，TNFR-III，TNFR-RP，Lymphotoxin beta Receptor，Tumor necrosis factor C receptor，Tumor Necrosis Factor Receptor 2-Related Protein，Lymphotoxin Beta Receptor (TNFR Superfamily， Member 3) |
| Approved Drugs | 0 |
| Drugs in Clinical Trials | 1 |
| Highest Development Stage | Phase 1 Clinical |
LTBR Product List
- Product Category
Protein (5)
- Product Status
Launched (5)
- Species
Human (3)Cynomolgus (1)Mouse (1)
- Tag
His Tag & Avi Tag (2)Fc Tag (1)His Tag (2)
- Conjugate
Biotin-labeled (1)Unconjugated (4)
| Cat. No. | Species | Host | Product Description | Structure | Purity | Feature |
|---|---|---|---|---|---|---|
HOT LTR-H5259 |  Human | HEK293 | Human LTBR / TNFRSF3 Protein, Fc Tag (MALS verified) |  |  |  |
HOT LTR-H52E3 | Human | HEK293 | Unconjugated Human LTBR / TNFRSF3 Protein, His,Avitag™ (MALS verified) |  | | |
HOT LTR-H82E9 | Human | HEK293 | Biotinylated Human LTBR / TNFRSF3 Protein, His,Avitag™ (MALS verified) |  | | |
LTR-M52H3 |  Mouse | HEK293 | Mouse LTBR / TNFRSF3 Protein, His Tag (MALS verified) |  | | |
LTR-C52H3 |  Cynomolgus | HEK293 | Cynomolgus LTBR / TNFRSF3 Protein, His Tag |  | | |
Total: 5
- 1
LTBR Background
Lymphotoxin-beta receptor (LTBR) is also known as Tumor necrosis factor receptor superfamily member 3 (TNFRSF3), Tumor necrosis factor receptor type III (TNF-RIII), which is a single-pass type I membrane protein containing four TNFR-Cys repeat regions. Except for interacting with HCV core protein, LTBR can not only associate with itself, but also can associate with TRAF3, TRAF4 and TRAF5. As the receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT, LTBR promotes apoptosis via TRAF3 and TRAF5. Furthermore, LTBR may play a role in the development of lymphoid organs.
LTBR Synonyms
LTBR,D12S370,TNFCR,TNFR3,TNFRSF3,TNFRIII
Clinical Drug Information
| English Name | Research Code | Highest Development Stage | Company | Indication | Clinical Trial |
|---|---|---|---|---|---|
| RO-7567132 | RO7567132; RO-7567132; RG-6221; RG6221 | Phase 1 Clinical | F. Hoffmann-La Roche Ag | Neoplasms; Solid tumours | Details |
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