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Home PageAll MoleculesMICA
MICA
MICA Overview
| English Name | MHC class I polypeptide-related sequence A | Approved Drugs | 0 |
| Drugs in Clinical Trials | 4 | Target Synonym | |
| Highest Development Stage | Phase 1 Clinical | ||
| English Name | MHC class I polypeptide-related sequence A |
| Target Synonym | |
| Approved Drugs | 0 |
| Drugs in Clinical Trials | 4 |
| Highest Development Stage | Phase 1 Clinical |
MICA Product List
- Product Category
Protein (10)
- Product Status
Launched (10)
- Species
Human (9)Cynomolgus (1)
- Tag
His Tag (3)Fc Tag (2)His Tag & Avi Tag (2)Fc Tag & Avi Tag (1)Mouse IgG Fc Tag (1)Human IgG4 Fc Tag (1)
- Conjugate
Unconjugated (7)Biotin-labeled (3)
| Cat. No. | Species | Host | Product Description | Structure | Purity | Feature |
|---|---|---|---|---|---|---|
HOT MIA-H5221 |  Human | HEK293 | Human MICA Protein, His Tag, low endotoxin (MALS verified) |  |  |  |
HOT MIA-H5253 | Human | HEK293 | Human MICA Protein, Fc Tag |  | | |
HOT MIA-H52H7 | Human | HEK293 | Human MICA (24-202) Protein, His Tag (MALS verified) |  | | |
HOT MIA-H82E4 | Human | HEK293 | Biotinylated Human MICA (201-309) Protein, His,Avitag™ (MALS verified) |  | | |
HOT MIA-H82E6 | Human | HEK293 | Biotinylated Human MICA Protein, His,Avitag™ (MALS verified) |  | | |
MIA-H5254 | Human | HEK293 | Human MICA (24-309) Protein, Fc Tag (MALS verified) |  | | |
MIA-H5255 | Human | HEK293 | Human MICA (24-202) Protein, Mouse IgG2a Fc Tag (MALS verified) |  | | |
MIA-H5259 | Human | HEK293 | Human MICA Protein, IgG4 Fc Tag |  | | |
MIA-H82F6 | Human | HEK293 | Biotinylated Human MICA Protein, Fc,Avitag™ (MALS verified) |  | | |
MIA-C52H5 |  Cynomolgus | HEK293 | Cynomolgus MICA Protein, His Tag (HPLC verified) |  | | |
Total: 10
- 1
MICA Background
MHC class I polypeptide-related sequence A (MICA) belongs to the MHC class I family and MIC subfamily. MICA contains one Ig-like C1-type (immunoglobulin-like) domain. Unlike classical MHC class I molecules, MICA does not form a heterodimer with beta-2-microglobulin. MICA acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. MICA is ligand for the KLRK1/NKG2D receptor. MICA bind to KLRK1 leads to cell lysis.
Clinical Drug Information
| English Name | Research Code | Highest Development Stage | Company | Indication | Clinical Trial |
|---|---|---|---|---|---|
| Isuventatug | CLN-619 | Phase 1 Clinical | Cullinan MICA Corp | Carcinoma, Non-Small-Cell Lung; Multiple Myeloma; Solid tumours | Details |
| FT-536 | FT-536 | Phase 1 Clinical | Fate Therapeutics Inc | Abdominal Neoplasms; Fallopian Tube Neoplasms; Genital Neoplasms, Female; Ovarian Neoplasms; Solid tumours | Details |
| FT-836 | FT-836; FT836 | Phase 1 Clinical | Fate Therapeutics Inc | Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Endometrial Neoplasms; Neoplasms; Ovarian Neoplasms; Squamous Cell Carcinoma of Head and Neck | Details |
| DM-919 | DM-919; DM919 | Phase 1 Clinical | D2M Biotherapeutics Inc | Neoplasms; Solid tumours | Details |
- Product List
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