MIF Overview
Molecule Name
Macrophage migration inhibitory factor
Synonyms
MIF,GLIF,MMIF,GIF
Drug Development Progress
Drugs in Clinical Trials3
Approved Drugs1
Highest Development StageApproved
Target Synonym
EC:5.3.2.1，GIF，EC 5.3.3.12，EC 5.3.2.1，Macrophage Migration-Inhibitory Factors，Epididymis Secretory Sperm Binding Protein，EC:5.3.3.12，Phenylpyruvate Tautomerase，L-Dopachrome Tautomerase，MMIF，Glycosylation-inhibiting factor，L-dopachrome isomerase，MIF，Macrophage Migration Inhibitory Factor，Macrophage Migration Inhibitory Factor (Glycosylation-Inhibiting Factor)，GLIF
Background
Macrophage migration inhibitory factor(MIF) is also known as Glycosylation-inhibiting factor(GIF), L-dopachrome isomerase, L-dopachrome tautomerase, Phenylpyruvate tautomerase. Interacts with CXCR2 extracellular domain, CD74 extracellular domain, COPS5 and BNIPL. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.
MIF Product List
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S***n2023-04-28This product was used for characterization of a novel therapeutic testing kinetics and affinity on SPR with a Cytiva BiotinCAPture kit. It worked phenomenally with both the novel approach and a positive control. Additionally, it was used with a Streptavidin coated ELISA plate (also from Acro), results were phenomenal with that approach as well. Overall, this product has been well received by our team and we have already ordered more to continue testing.