Nav1.6

Nav 1.6, encoded by the SCN8A gene, is a voltage-gated sodium channel highly concentrated at the axon initial segment and nodes of Ranvier. It plays a pivotal role in initiating action potentials and generating persistent currents. Gain-of-function mutations drive severe developmental epileptic encephalopathies, making Nav 1.6 a premier target for subtype-selective inhibitors. This product is focusing on C-terminus Truncation.