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NOTCH3

NOTCH3 Overview

English NameNeurogenic locus notch homolog protein 3Approved Drugs0
Drugs in Clinical Trials0Target SynonymNeurogenic Locus Notch Homolog Protein 3，LMNS，Notch 3，NOTCH3，Notch (Drosophila) Homolog 3，Notch Homolog 3 (Drosophila)，Notch Homolog 3，CADASIL1，CADASIL，CASIL，IMF2，Receptor， Notch3，Notch Receptor 3
Highest Development StagePreclinical
English NameNeurogenic locus notch homolog protein 3
Target SynonymNeurogenic Locus Notch Homolog Protein 3，LMNS，Notch 3，NOTCH3，Notch (Drosophila) Homolog 3，Notch Homolog 3 (Drosophila)，Notch Homolog 3，CADASIL1，CADASIL，CASIL，IMF2，Receptor， Notch3，Notch Receptor 3
Approved Drugs0
Drugs in Clinical Trials0
Highest Development StagePreclinical

NOTCH3 Product List

  • Product Category

    Protein (1)

  • Product Status

    Launched (1)

  • Species

    Human (1)

  • Tag

    Fc Tag (1)

  • Conjugate

    Unconjugated (1)

Total: 1
  • 1

NOTCH3 Background

Notch3 is one of four mammalian Notch proteins, which act as signalling receptors and involve in developmental patterning, cell fate decisions, regulation of cell survival and proliferation. Notch3 could interact with membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Via ligand activation, notch intracellular domain (NICD) is released and forms a transcriptional activator RBPJ/RBPSUH complex, which activates genes of the enhancer of split locus. Consequently, the activation of Notch3 can lead to the implementation of differentiation, proliferation and apoptotic programs

NOTCH3 Synonyms

Notch-3,NOTCH3
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