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Osteopontin

Osteopontin Overview

English NameOsteopontinApproved Drugs0
Drugs in Clinical Trials0Target SynonymSecreted Phosphoprotein 1 (Osteopontin， Bone Sialoprotein I， Early T-Lymphocyte Activation 1)，Osteopontin/Immunoglobulin Alpha 1 Heavy Chain Constant Region Fusion Protein，Secreted Phosphoprotein 1 Variant 6，SPP1/CALPHA1 Fusion，ETA-1，BSPI，SPP-1，Bone sialoprotein 1，BNSP，Urinary stone protein，PSEC0156，OPN，Uropontin，SPP1，Secreted Phosphoprotein 1，Early T-Lymphocyte Activation 1，Nephropontin，Osteopontin，Bone Sialoprotein I
Highest Development StagePreclinical
English NameOsteopontin
Target SynonymSecreted Phosphoprotein 1 (Osteopontin， Bone Sialoprotein I， Early T-Lymphocyte Activation 1)，Osteopontin/Immunoglobulin Alpha 1 Heavy Chain Constant Region Fusion Protein，Secreted Phosphoprotein 1 Variant 6，SPP1/CALPHA1 Fusion，ETA-1，BSPI，SPP-1，Bone sialoprotein 1，BNSP，Urinary stone protein，PSEC0156，OPN，Uropontin，SPP1，Secreted Phosphoprotein 1，Early T-Lymphocyte Activation 1，Nephropontin，Osteopontin，Bone Sialoprotein I
Approved Drugs0
Drugs in Clinical Trials0
Highest Development StagePreclinical

Osteopontin Product List

  • Product Category

    Protein (3)

  • Product Status

    Launched (3)

  • Species

    Human (2)Mouse (1)

  • Tag

    His Tag (1)His Tag & Avi Tag (2)

  • Conjugate

    Unconjugated (1)Biotin-labeled (2)

Cat. No.SpeciesHostProduct DescriptionStructurePurityFeature
OPN-H5227
Human
HEK293
Human Osteopontin (OPN) Protein, His Tag, premium grade
OPN-H82E8
Human
HEK293
Biotinylated Human Osteopontin (OPN) Protein, His,Avitag™
OPN-M82E8
Mouse
HEK293
Biotinylated Mouse Osteopontin (OPN) Protein, His,Avitag™
Total: 3
  • 1

Osteopontin Background

Osteopontin (OPN) is also known as Secreted phosphoprotein 1 (SPP1), Bone sialoprotein 1, Nephropontin, Urinary stone protein, Uropontin, BNSP, which belongs to the osteopontin family. OPN / SPP1 is a highly negatively charged, extracellular matrix protein that lacks an extensive secondary structure. Full length OPN (OPN-FL) can be modified by thrombin cleavage, which exposes a cryptic sequence, SVVYGLR on the cleaved form of the protein known as OPN-R. Osteopontin / SPP-1 is biosynthesized by a variety of tissue types. OPN is the ligand for integrin alpha-V/beta-3. OPN / SPP1 binds tightly to hydroxyapatite and appears to form an integral part of the mineralized matrix. OPN / SPP1 probably important to cell-matrix interaction. OPN / SPP1 acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity.

Osteopontin Synonyms

SPP1,BNSP,OPN,Uropontin,Nephropontin,Osteopontin,BSP-1,ETA-1,BSPI
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