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Home PageAll MoleculesPLAU
PLAU
PLAU Overview
| English Name | Urokinase plasminogen activator | Approved Drugs | 4 |
| Drugs in Clinical Trials | 5 | Target Synonym | PLAU，uPA，Plasminogen Activator， Urokinase，Urokinase-Type Plasminogen Activator，Plasminogen Activator， Urinary，BDPLT5，U-PA，ATF，QPD，URK，EC 3.4.21，EC:3.4.21.73，U-Plasminogen Activator，EC 3.4.21.73 |
| Highest Development Stage | Approved | ||
| English Name | Urokinase plasminogen activator |
| Target Synonym | PLAU，uPA，Plasminogen Activator， Urokinase，Urokinase-Type Plasminogen Activator，Plasminogen Activator， Urinary，BDPLT5，U-PA，ATF，QPD，URK，EC 3.4.21，EC:3.4.21.73，U-Plasminogen Activator，EC 3.4.21.73 |
| Approved Drugs | 4 |
| Drugs in Clinical Trials | 5 |
| Highest Development Stage | Approved |
PLAU Product List
- Product Category
Protein (2)
- Product Status
Launched (2)
- Species
Human (2)
- Tag
His Tag (2)
- Conjugate
Unconjugated (2)
| Cat. No. | Species | Host | Product Description | Structure | Purity | Feature |
|---|---|---|---|---|---|---|
PLU-H5228 |  Human | HEK293 | Human PLAU / uPA Protein, His Tag (activated by trypsin) (active enzyme) |  |  | |
PLU-H5229 | Human | HEK293 | Human PLAU / uPA Protein, His Tag |  | |  |
Total: 2
- 1
PLAU Background
Urokinase - type plasminogen activator is also known as PLAU and UPA, a serine protease with an extremely limited substrate specificity, cleaving the sequence Cys – Pro – Gly - Arg560 - Val561 – Val – Gly – Gly – Cys in plasminogen to form plasmin. uPA is a potent marker of invasion and metastasis in a variety of human cancers associated with breast, stomach, colon, bladder, ovary, brain and endometrium.uPA and its receptor (uPAR) have been implicated in a broad spectrum of pathophysiological processes, including fibrinolysis, proteolysis, inflammation, atherogenesis and plaque destabilization, all of which are involved in the pathogenesis of MI (myocardial infarction).
PLAU Synonyms
Urokinase,PLAU,ATF,UPA,URK,u-PA,BDPLT5,QPD
Clinical Drug Information
| English Name | Research Code | Highest Development Stage | Company | Indication | Clinical Trial |
|---|---|---|---|---|---|
| tPA/HisproUK (Thrombolytic Science) | TS-01 | Phase 2 Clinical | Thrombolytic Science | Ischemic Stroke | Details |
| Upamostat Hydrogen Sulphate | WX-671; LH-011; RHB-107 | Phase 2 Clinical | Wilex AG | Coronavirus Disease 2019 (COVID-19); Metastatic breast cancer; Pancreatic Neoplasms | Details |
| Microlyse | TGD-001 | Phase 2 Clinical | University Medical Centre Utrecht, Netherlands | Ischemic Stroke; Purpura, Thrombotic Thrombocytopenic; Thrombocytopenia; Thrombotic Microangiopathies | Details |
| Recombinant annexin A5 (Annexin Pharmaceuticals) | ANXV; ANXV (Annexin A5); ANXV (Human Recombinant Annexin A5) | Phase 2 Clinical | Annexin Pharmaceuticals AB | Anemia, Sickle Cell; Cardiovascular Diseases; Diabetic Retinopathy; Neoplasms; Retinal Vein Occlusion | Details |
| MSB-03 | MSB-03 | Phase 1 Clinical | MatriSys Bioscience Inc | Rosacea | Details |
Marketed Drug Information
| English Name | Research Code | Highest Development Stage | Company | Earliest Brand Name | Earliest Approval Country | Earliest Indication | Earliest Approval Company | Earliest Approval Date | Indication | Clinical Trial |
|---|---|---|---|---|---|---|---|---|---|---|
| Urokinase biosimilar (Sedico) | Approved | Sedico | Angikinase | Egypt | Thromboembolism; Myocardial Infarction; Pulmonary Embolism | Sedico | 2014-01-01 | Myocardial Infarction; Pulmonary Embolism; Thromboembolism | Details | |
| Tisokinase | AK-124 | Approved | Asahi Kasei Corp, Kowa Dental Health Co Ltd | Plasvata, Hapase | Japan | Myocardial Infarction; Thrombosis | null | 1991-01-01 | Myocardial Infarction; Thrombosis | Details |
| Urokinase biosimilar (Bharat Serums & Vaccines) | U-FRAG | Approved | Bharat Serums And Vaccines Ltd | Pulmonary Embolism | Details | |||||
| Nasaruplase | GE-0943 | Approved | Mitsubishi Pharma Corp | Tomieze, Thrombolyse | Japan | Myocardial Infarction; Venous Thrombosis | Mitsubishi Pharma Corp | 1992-01-01 | Myocardial Infarction; Venous Thrombosis | Details |
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