Postfusion glycoprotein B/Postfusion gB (HSV)

Herpes simplex viruses (HSV)-1 and HSV-2 cause a variety of human diseases, including encephalitis, keratitis, neonatal disease, and mucocutaneous and skin diseases such as herpes labialis, genital herpes, and herpetic whitlow. HSV-1 gB, which is a class III fusion glycoprotein, is a major target of antibody-mediated immunity (21). It plays an essential role in the entry of the virus into a host cell, together with other HSV-1 envelope glycoproteins, including gD and a complex of gH and gL (gH/gL).