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RAGE

RAGE Overview

English NameAdvanced glycosylation end product-specific receptorApproved Drugs0
Drugs in Clinical Trials3Target SynonymReceptor for advanced glycosylation end products，AGER，Advanced Glycosylation End-Product Specific Receptor，RAGE，Receptor For Advanced Glycation End-Products Variant 20，Receptor For Advanced Glycation End-Products，RAGE Isoform NtRAGE-Delta，RAGE Isoform SRAGE-Delta，SCARJ1，Receptor for Advanced Glycation End Products，Advanced glycosylation end product-specific receptor
Highest Development StagePhase 3 Clinical
English NameAdvanced glycosylation end product-specific receptor
Target SynonymReceptor for advanced glycosylation end products，AGER，Advanced Glycosylation End-Product Specific Receptor，RAGE，Receptor For Advanced Glycation End-Products Variant 20，Receptor For Advanced Glycation End-Products，RAGE Isoform NtRAGE-Delta，RAGE Isoform SRAGE-Delta，SCARJ1，Receptor for Advanced Glycation End Products，Advanced glycosylation end product-specific receptor
Approved Drugs0
Drugs in Clinical Trials3
Highest Development StagePhase 3 Clinical

RAGE Product List

  • Product Category

    Cell (1)

  • Product Status

    Launched (1)

  • Species

    Human (1)

  • Tag

    - (1)

  • Conjugate

    - (1)

Cat. No.SpeciesHostProduct DescriptionStructurePurityFeature
CHEK-ATP156
Human
HEK293
HEK293/Human RAGE Stable Cell Line
Total: 1
  • 1

RAGE Background

Advanced glycosylation end product-specific receptor (AGER) is also known as RAGE, and is a single-pass type I membrane protein which contains two Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. AGER is highly expressed in endothelial cells. AGER mediates interactions of advanced glycosylation end products (AGE), and also accumulates in vascular tissue in aging and at an accelerated rate in diabetes, as well as acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGER / RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes.

RAGE Synonyms

AGER,RAGE

Clinical Drug Information

English NameResearch CodeHighest Development StageCompanyIndicationClinical Trial
AzeliragonTTP-488; PF-4494700; PF-04494700Phase 3 ClinicalVtv TherapeuticsAlzheimer Disease; Brain metastases; Breast Neoplasms; Coronavirus Disease 2019 (COVID-19); Diabetic Nephropathies; Glioblastoma; Glioma; Neoplasm Metastasis; Neoplasms; Pancreatic Neoplasms
Details
TRC-4186TX-41XX; TRC-4186Phase 2 ClinicalTorrent Pharmaceuticals LtdDiabetes Complications; Heart Failure
Details
ARO-RAGEPhase 2 ClinicalArrowhead Pharmaceuticals IncAsthma
Details
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