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SIGIRR
SIGIRR Product List
- Product Category
Protein (1)
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Launched (1)
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Human (1)
- Tag
Fc Tag (1)
- Conjugate
Unconjugated (1)
| Cat. No. | Species | Host | Product Description | Structure | Purity | Feature | Order Now |
|---|---|---|---|---|---|---|---|
SIR-H5255 |  Human | HEK293 | Human SIGIRR Protein, Fc Tag (MALS verified) |  |  |  Add to Cart |
Total: 1
- 1
SIGIRR Background
Single immunoglobulin IL-1-related receptor (SIGIRR), which is also known as Toll/interleukin-1 receptor 8, is a member of the interleukin-1 receptor (IL-1R) family. SIGIRR acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.
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