Select Language
SMO
SMO Overview
| English Name | Smoothened receptor | Approved Drugs | 3 |
| Drugs in Clinical Trials | 5 | Target Synonym | SMO，SMOH，Smoothened， Frizzled Class Receptor，Smoothened， Frizzled Family Receptor，Frizzled Family Member 11，Protein Gx，Seven Transmembrane Helix Receptor，Smoothened Homolog (Drosophila)，Smoothened Homolog，FZD11，CRJS，Gx，Smoothened Receptor，Smoothened， Seven Transmembrane Spanning Receptor，Smoothened (Drosophila) Homolog |
| Highest Development Stage | Approved | ||
| English Name | Smoothened receptor |
| Target Synonym | SMO，SMOH，Smoothened， Frizzled Class Receptor，Smoothened， Frizzled Family Receptor，Frizzled Family Member 11，Protein Gx，Seven Transmembrane Helix Receptor，Smoothened Homolog (Drosophila)，Smoothened Homolog，FZD11，CRJS，Gx，Smoothened Receptor，Smoothened， Seven Transmembrane Spanning Receptor，Smoothened (Drosophila) Homolog |
| Approved Drugs | 3 |
| Drugs in Clinical Trials | 5 |
| Highest Development Stage | Approved |
SMO Product List
- Product Category
Protein (2)
- Product Status
Launched (2)
- Species
Human (2)
- Tag
- (2)
- Conjugate
Unconjugated (2)
| Cat. No. | Species | Host | Product Description | Structure | Purity | Feature | Order Now |
|---|---|---|---|---|---|---|---|
SMO-H52D3 |  Human | HEK293 | Human SMO Protein, His,Flag Tag (Detergent) |  |  |  Add to Cart | |
SMO-H52P3 | Human | HEK293 | Human SMO Full Length Protein (VLP) | | Add to Cart |
Total: 2
- 1
SMO Background
The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex.
SMO Synonyms
SMO,smoothened, frizzled class receptor,CRJS, FZD11, Gx, PHLS, SMOH
Clinical Drug Information
| English Name | Research Code | Highest Development Stage | Company | Indication | Clinical Trial |
|---|---|---|---|---|---|
| Patidegib | SGT-610; BBP-009; FIN-5; IPI-926 | Phase 3 Clinical | Infinity Pharmaceuticals Inc | Adenocarcinoma; Basal Cell Nevus Syndrome; Carcinoma, Basal Cell; Chondrosarcoma; Head and Neck Neoplasms; Neoplasms; Pancreatic Neoplasms; Primary Myelofibrosis | Details |
| Taladegib | ENV-IPF-101; ENV-ONC-101; LY-2940680; ENV-101; RXDX-109 | Phase 2 Clinical | Eli Lilly And Company | Breast Neoplasms; Cholangiocarcinoma; Colonic Neoplasms; Idiopathic Pulmonary Fibrosis; Medulloblastoma; Neoplasm Metastasis; Neoplasms; Rhabdomyosarcoma; Sarcoma; Small Cell Lung Carcinoma; Solid tumours | Details |
| GT-1708F | GT-1708F; GT-1708; GT1708F | Phase 2 Clinical | Suzhou Koshine Biomedica Inc | Hematologic Neoplasms; Idiopathic Pulmonary Fibrosis; Solid tumours | Details |
| Cipromedegib | SHR-1539 | Phase 1 Clinical | Jiangsu Hengrui Medicine Co Ltd | Solid tumours | Details |
| ZSP-1602 | ZSP-1602 | Phase 1 Clinical | Guangdong Zhongsheng Pharmaceutical Co Ltd | Carcinoma; Carcinoma, Basal Cell; Carcinoma, Neuroendocrine; Esophageal Neoplasms; Glioblastoma; Glioma; Medulloblastoma; Neoplasms; Neuroendocrine Tumors; Pancreatic Neoplasms; Small Cell Lung Carcinoma; Stomach Neoplasms | Details |
Marketed Drug Information
| English Name | Research Code | Highest Development Stage | Company | Earliest Brand Name | Earliest Approval Country | Earliest Indication | Earliest Approval Company | Earliest Approval Date | Indication | Clinical Trial |
|---|---|---|---|---|---|---|---|---|---|---|
| Sonidegib Diphosphate | LDE-225; NVP-LDE-225 | Approved | Novartis Pharma Ag | Odomzo, 奥昔朵 | United States | Carcinoma, Basal Cell | Sun Pharmaceutical Industries Ltd | 2015-07-24 | Astrocytoma; Basal Cell Nevus Syndrome; Blood Coagulation Disorders; Blood Platelet Disorders; Bone Marrow Diseases; Breast Neoplasms; Carcinoma, Basal Cell; Carcinoma, Hepatocellular; Carcinoma, Pancreatic Ductal; Colorectal Neoplasms; Esophageal Neoplasms; Gastroesophageal Junction Neoplasms; Glioblastoma; Glioma; Graft vs Host Disease; Hematologic Diseases; Hematologic Neoplasms; Hemorrhagic Disorders; Hepatic Insufficiency; Hepatoblastoma; HR-positive breast cancer; Leukemia; Leukemia, Myelogenous, Chronic; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Liver Cirrhosis; Liver Dysfunction; Lung Neoplasms; Medulloblastoma; Metastatic breast cancer; Multiple Myeloma; Myelodysplastic Syndromes; Myelodysplastic-Myeloproliferative Diseases; Myeloproliferative Disorders; Neuroblastoma; Ovarian Neoplasms; Pancreatic Neoplasms; Polycythemia Vera; Primary Myelofibrosis; Prostatic Neoplasms; Rhabdomyosarcoma; Skin Neoplasms; Solid tumours; Stomach Neoplasms; Thrombocythemia, Essential; Thrombocytosis; | Details |
| Glasdegib | PF-04; PF-4449913; PF-04449913 | Approved | Pfizer Inc | Daurismo | United States | Leukemia, Myeloid, Acute | Pfizer Inc | 2018-11-21 | Fasciitis; Graft vs Host Disease; Hematologic Neoplasms; Hepatic Insufficiency; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Myelodysplastic Syndromes; Primary Myelofibrosis; Renal Insufficiency; Solid tumours | Details |
| Vismodegib | R-3616; RG-3616; GDC-0449 | Approved | F. Hoffmann-La Roche Ltd, Genentech Inc | Erivedge | United States | Carcinoma, Basal Cell | Genentech Inc | 2012-01-30 | Adenocarcinoma; Basal Cell Nevus Syndrome; Brain Neoplasms; Breast Neoplasms; Carcinoma, Basal Cell; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Central Nervous System Lymphoma; Chondrosarcoma; Chondrosarcoma, Clear Cell; Chondrosarcoma, Extraskeletal Myxoid; Chondrosarcoma, Mesenchymal; Colorectal Neoplasms; Dermatofibrosarcoma; Desmoplastic Small Round Cell Tumor; Esophageal Neoplasms; Fibrosarcoma; Gastrointestinal Stromal Tumors; Glioblastoma; Gliosarcoma; Graft vs Host Disease; Hemangioendothelioma, Epithelioid; Hemangiosarcoma; Hematologic Neoplasms; Idiopathic Pulmonary Fibrosis; Leiomyosarcoma; Leukemia, Lymphocytic, Chronic, B-Cell; Liposarcoma; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Medulloblastoma; Mesenchymoma; Multiple Myeloma; Neoplasms; Neuroectodermal Tumors, Primitive, Peripheral; Neurofibrosarcoma; Odontogenic Cyst, Calcifying; Osteosarcoma; Ovarian Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms; Rhabdomyosarcoma; Sarcoma; Sarcoma, Alveolar Soft Part | Details |
- Overview
- Product List
- Marketed Drug Information
- Clinical Drug Information
Share to:
Online Message
Contact Us
[North America]: +1 800-810-0816
[Switzerland]: +41 800 040 012
[Asia & Pacific]: +86 400-682-2521
[North America]: 1 Innovation Way, Newark, DE 19711, USA
[Switzerland]: ACRObiosystems AG, c/o Zug Dammstrasse Centre AG, Dammstrasse 19, 6300 Zug Switzerland