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Menu
Home PageAll MoleculesSortilin
Sortilin
Sortilin Overview
| English Name | Sortilin | Approved Drugs | 0 |
| Drugs in Clinical Trials | 3 | Target Synonym | 100 kDa NT receptor，NT3，Glycoprotein 95，LDLCQ6，NTR3，Gp95，Sortilin 1，Neurotensin receptor 3 |
| Highest Development Stage | Phase 2 Clinical | ||
| English Name | Sortilin |
| Target Synonym | 100 kDa NT receptor，NT3，Glycoprotein 95，LDLCQ6，NTR3，Gp95，Sortilin 1，Neurotensin receptor 3 |
| Approved Drugs | 0 |
| Drugs in Clinical Trials | 3 |
| Highest Development Stage | Phase 2 Clinical |
Sortilin Product List
- Product Category
Protein (5)Cell (1)
- Product Status
Launched (6)
- Species
Human (3)Cynomolgus (1)Rat (1)Canine (1)
- Tag
His Tag (4)His Tag & Avi Tag (1)- (1)
- Conjugate
Unconjugated (4)Biotin-labeled (1)- (1)
| Cat. No. | Species | Host | Product Description | Structure | Purity | Feature | Order Now |
|---|---|---|---|---|---|---|---|
CHEK-ATP155 |  Human | HEK293 | HEK293/Human SORT1 Stable Cell Line |  |  Add to Cart | ||
SON-H52H5 | Human | HEK293 | Human Sortilin / SORT1 Protein, His Tag, low endotoxin (MALS verified) |  |  | Add to Cart | |
SON-H82E9 | Human | HEK293 | Biotinylated Human Sortilin / SORT1 Protein, His,Avitag™ (MALS & SPR verified) |  | |  | Add to Cart |
SON-C52H3 |  Cynomolgus | HEK293 | Cynomolgus Sortilin Protein, His Tag |  | | Add to Cart | |
SON-C52H4 |  Canine | HEK293 | Canine Sortilin Protein, His Tag |  | | Add to Cart | |
SON-R52H3 |  Rat | HEK293 | Rat Sortilin Protein, His Tag (MALS verified) |  | | Add to Cart |
Total: 6
- 1
Sortilin Background
The Sortilin is a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Lysosomal proteins bind specifically to the receptor in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer.
Sortilin Synonyms
Sortilin,SORT1,100 kDa NT receptor,Glycoprotein 95,Gp95,Gp95LDLCQ6,Neurotensin receptor 3,NT3NTR3,Ntr3,sortilin 1,
Clinical Drug Information
| English Name | Research Code | Highest Development Stage | Company | Indication | Clinical Trial |
|---|---|---|---|---|---|
| VES-001 | VES001; VES-001 | Phase 2 Clinical | Vesper Bio APS | Dementia; Frontotemporal Dementia; Frontotemporal Lobar Degeneration | Details |
| Latozinemab | AL-001; GSK-4527223 | Phase 1 Clinical | Alector Inc, Glaxosmithkline Plc | Amyotrophic Lateral Sclerosis; Frontotemporal Dementia; Neurodegenerative Diseases | Details |
| ARB-1-6 | ARB-1-6; PQ-203 | Phase 1 Clinical | ProteinQure Inc | Breast Neoplasms; Solid tumours; Triple Negative Breast Neoplasms | Details |
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