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Home PageAll MoleculesSTEAP1
STEAP1
STEAP1 Overview
| English Name | Six-transmembrane epithelial antigen of the prostate 1 | Approved Drugs | 0 |
| Drugs in Clinical Trials | 7 | Target Synonym | PRSS24，Six-transmembrane epithelial antigen of prostate 1，STEAP，STEAP1，STEAP Family Member 1，Six Transmembrane Epithelial Antigen Of The Prostate 1，STEAP1 Metalloreductase，Six Transmembrane Epithelial Antigen Of The Prostate，Metalloreductase STEAP1，EC 1.16.1.-，EC:1.16.1.- |
| Highest Development Stage | Phase 3 Clinical | ||
| English Name | Six-transmembrane epithelial antigen of the prostate 1 |
| Target Synonym | PRSS24，Six-transmembrane epithelial antigen of prostate 1，STEAP，STEAP1，STEAP Family Member 1，Six Transmembrane Epithelial Antigen Of The Prostate 1，STEAP1 Metalloreductase，Six Transmembrane Epithelial Antigen Of The Prostate，Metalloreductase STEAP1，EC 1.16.1.-，EC:1.16.1.- |
| Approved Drugs | 0 |
| Drugs in Clinical Trials | 7 |
| Highest Development Stage | Phase 3 Clinical |
STEAP1 Product List
- Product Category
Cell (2)Protein (4)
- Product Status
Launched (6)
- Species
Human (5)Rat (1)
- Tag
- (1)His Tag & Strep Tag (2)Tag Free (1)His Tag & Avi Tag & Flag Tag (1)His Tag & Flag Tag (1)
- Conjugate
- (2)Unconjugated (3)Biotin-labeled (1)
| Cat. No. | Species | Host | Product Description | Structure | Purity | Feature |
|---|---|---|---|---|---|---|
HOT CHEK-ATP154 |  Human | HEK293 | HEK293/Human STEAP1 Stable Cell Line |  | ||
HOT ST1-H5283 | Human | HEK293 | Human STEAP1 Full Length Protein, Twin-Strep,His Tag (Detergent) (SPR verified) |  |  |  |
HOT ST1-H82D3 | Human | HEK293 | Biotinylated Human STEAP1 Full Length Protein, Avitag™,Flag&His Tag (Detergent) |  | | |
SCCHO-ATP121 | Human | CHO | CHO/Human STEAP1 Stable Cell Line | | ||
ST1-H5286 | Human | HEK293 | Human STEAP1 Full Length Protein, Twin-Strep,His Tag (Nanodisc) |  | | |
ST1-R52D3 |  Rat | HEK293 | Rat STEAP1 Protein, Flag,His Tag (Detergent) |  | | |
Total: 6
- 1
STEAP1 Background
Six-transmembrane epithelial antigen of the prostate 1 (STEAP1) is an integral membrane protein that is highly up-regulated on the cell surface of several human cancers, making it a promising therapeutic target to manage these diseases. It shares sequence homology with three enzymes (STEAP2-STEAP4) that catalyze the NADPH-dependent reduction of iron(III). Taking into account its high specificity and overexpression in human cancers, STEAP1 is nowadays a promising candidate to be imposed as a therapeutic target.
STEAP1 Synonyms
STEAP1, PRSS24, STEAP
Clinical Drug Information
| English Name | Research Code | Highest Development Stage | Company | Indication | Clinical Trial |
|---|---|---|---|---|---|
| Xaluritamig | AMG-509 | Phase 3 Clinical | Amgen Inc, Xencor Inc | Castration-Sensitive Prostate Neoplasms; Hormone-Sensitive Prostate Neoplasms; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Sarcoma, Ewing | Details |
| 89Zr-DFO-MSTP2109A | Phase 2 Clinical | Genentech Inc, Memorial Sloan Kettering Cancer Center | Prostatic Neoplasms | Details | |
| STEAP1 CART Cell Therapy(PromiCell) | Phase 2 Clinical | Fred Hutchinson Cancer Research Center, PromiCell Therapeutics Inc | Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant | Details | |
| PRO CAR-201A | PRO CAR-201A | Phase 1 Clinical | Fred Hutchinson Cancer Research Center | Prostatic Neoplasms, Castration-Resistant | Details |
| ABBV-969 | ABBV-969; ABBV969 | Phase 1 Clinical | Abbvie Inc | Prostatic Neoplasms, Castration-Resistant | Details |
| ADRX-0405 | ADRX-0405 | Phase 1 Clinical | Adcentrx Therapeutics Inc | Neoplasms; Solid tumours | Details |
| DXC-008 | DAC-008; DXC-008 | Phase 1 Clinical | Hangzhou Dac Biotech Company Ltd | Prostatic Neoplasms; Sarcoma, Ewing; Solid tumours | Details |
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