SUSD6

SUSD6 is a Type I transmembrane protein, the extracellular portion of which contains a characteristic Sushi domain (also known as a Complement Control Protein domain). This domain typically mediates protein-protein interactions. Dysregulated expression of SUSD6 is closely associated with the pathogenesis, progression, and prognosis of various cancers. Its core characteristics lie in its ability to promote apoptosis via the DR5 pathway and its dualistic role across different cancer types.