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TIGIT

TIGIT

TIGIT Overview

Molecule Name
T cell immunoglobulin and ITIM domains
Synonyms
TIGIT,VSIG9,VSTM3
Drug Development Progress
Drugs in Clinical Trials40
Approved Drugs0
Highest Development StagePhase 3 Clinical
Target Synonym
V-Set And Immunoglobulin Domain Containing 9，Washington University Cell Adhesion Molecule，V-Set And Transmembrane Domain Containing 3，WUCAM，DKFZp667A205，FLJ39873，V-set and immunoglobulin domain-containing protein 9，TIGIT，VSIG9，T Cell Immunoreceptor With Ig And ITIM Domains，V-Set And Transmembrane Domain-Containing Protein 3，VSIG9， VSTM3，VSTM3，T-Cell Immunoreceptor With Ig And ITIM Domains
Background
T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is also known as V-set and immunoglobulin domain-containing protein 9 (VSIG9), V-set and transmembrane domain-containing protein 3 (VSTM3),which belongs to single-pass type I membrane protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT is expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level). TIGIT binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.

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