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Home PageAll MoleculesTNFR1
TNFR1
TNFR1 Overview
| English Name | Tumor necrosis factor receptor superfamily member 1A | Approved Drugs | 0 |
| Drugs in Clinical Trials | 2 | Target Synonym | Tumor necrosis factor receptor 1，TNF-R1，Tumor necrosis factor receptor type I，TNF-RI，TNFR-I，CD120a，TNF Receptor Superfamily Member 1A，TNFAR，Tumor Necrosis Factor Receptor Superfamily Member 1A，TNF-R-I，TNF-R55，TNFR60，TNF-R，TNFR1，Tumor Necrosis Factor Receptor Superfamily， Member 1A，Tumor Necrosis Factor Receptor 1A Isoform Beta，Tumor Necrosis Factor Binding Protein 1，Tumor Necrosis Factor Receptor Type 1，Tumor Necrosis Factor Receptor Type I，Tumor Necrosis Factor-Alpha Receptor，Tumor Necrosis Factor Receptor 1，CD120a Antigen，TNFRSF1A，TNFR55，P55-R，TBP1，FPF，TBPI，p55，p60 |
| Highest Development Stage | Phase 3 Clinical | ||
| English Name | Tumor necrosis factor receptor superfamily member 1A |
| Target Synonym | Tumor necrosis factor receptor 1，TNF-R1，Tumor necrosis factor receptor type I，TNF-RI，TNFR-I，CD120a，TNF Receptor Superfamily Member 1A，TNFAR，Tumor Necrosis Factor Receptor Superfamily Member 1A，TNF-R-I，TNF-R55，TNFR60，TNF-R，TNFR1，Tumor Necrosis Factor Receptor Superfamily， Member 1A，Tumor Necrosis Factor Receptor 1A Isoform Beta，Tumor Necrosis Factor Binding Protein 1，Tumor Necrosis Factor Receptor Type 1，Tumor Necrosis Factor Receptor Type I，Tumor Necrosis Factor-Alpha Receptor，Tumor Necrosis Factor Receptor 1，CD120a Antigen，TNFRSF1A，TNFR55，P55-R，TBP1，FPF，TBPI，p55，p60 |
| Approved Drugs | 0 |
| Drugs in Clinical Trials | 2 |
| Highest Development Stage | Phase 3 Clinical |
TNFR1 Product List
- Product Category
Protein (10)
- Product Status
Launched (10)
- Species
Human (5)Human & Mouse (2)Porcine (1)Cynomolgus (1)Mouse (1)
- Tag
His Tag (5)Fc Tag (1)Fc Tag & Avi Tag (1)His Tag & Avi Tag (3)
- Conjugate
Unconjugated (6)Biotin-labeled (4)
Add to Cart
Total: 10
- 1
TNFR1 Background
Tumor necrosis factor receptor 1 (TNF-R1) is also known as Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A), TNFAR, CD antigen CD120a, which belongs to the tumor necrosis factor receptor superfamily. TNF-R1 contains one death domain and four TNFR-Cys repeats. TNF-R1 is the receptor of TNFSF2 / TNF-alpha and homotrimeric TNFSF1 / lymphotoxin - alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TNF-R1 contributes to the induction of non - cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. Defects in TNFRSF1A are the cause of familial hibernian fever (FHF).
TNFR1 Synonyms
TNFR1,CD120a,TNFRSF1A,FPF,TBP1,TNF-R,TNF-R-I,TNF-R55,TNFAR,TNFR55,TNFR60,p55,p60
Clinical Drug Information
| English Name | Research Code | Highest Development Stage | Company | Indication | Clinical Trial |
|---|---|---|---|---|---|
| Ofranergene obadenovec | GT-111; VB-111 | Phase 3 Clinical | Vascular Pharmaceuticals Inc | Colorectal Neoplasms; Glioblastoma; Neoplasms; Neuroendocrine Tumors; Ovarian Neoplasms; Thyroid Carcinoma, Anaplastic | Details |
| Atrosab | Phase 1 Clinical | Celonic | Inflammation | Details |
Product Reviews
E***a2024-11-13
0People LikeI was able to get this protein shipped overnight and use it for Octet and SPR experiments. Quality is amazing and the biotinylated protein works great!- 1***22019-10-10 0People LikeThe quality of TNFR1 protein is pretty good. I performed the SDS-PAGE. The result shown as below is similar to the result on ACRO's official website. The purity is good, and the position is also the same.
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