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TRBC1

TRBC1 Overview

English NameTRBC1Approved Drugs0
Drugs in Clinical Trials4Target SynonymT cell receptor beta constant 1，TRBC1，V_segment Translation Product，BV05S1J2.2，TCRBC1，TCRB
Highest Development StagePhase 2 Clinical
English NameTRBC1
Target SynonymT cell receptor beta constant 1，TRBC1，V_segment Translation Product，BV05S1J2.2，TCRBC1，TCRB
Approved Drugs0
Drugs in Clinical Trials4
Highest Development StagePhase 2 Clinical

TRBC1 Product List

  • Product Category

    Protein (2)

  • Product Status

    Launched (2)

  • Species

    Human (2)

  • Tag

    His Tag (1)His Tag & Avi Tag (1)

  • Conjugate

    Unconjugated (1)Biotin-labeled (1)

Cat. No.SpeciesHostProduct DescriptionStructurePurityFeature
TR1-H52H4
Human
HEK293
Human TRBC1 Protein, His Tag (HPLC verified)
TR1-H82E6
Human
HEK293
Biotinylated Human TRBC1 Protein, His,Avitag™
Total: 2
  • 1

TRBC1 Background

The transmembrane protein, TCR, comprise of two disulphide-linked polypeptide chains: a α and β chain, a γ and δ chain. Each polypeptide chain consists of a variable and a constant region. TRBC1 is the constant region of T-cell receptor (TCR) beta chain. TRBC1 is presented on the surface of T cell and recognized peptide-major histocompatibility (MH) (pMH) that are displayed by antigen presenting cells (APC). TRBC1 is participate in an adaptive immune response and has been well-studied in T cell therapy.

TRBC1 Synonyms

T cell receptor beta constant 1,TRBC1

Clinical Drug Information

English NameResearch CodeHighest Development StageCompanyIndicationClinical Trial
Invikafusp AlfaSTAR0602; STAR-0602Phase 2 ClinicalMarengo Therapeutics IncAbdominal Neoplasms; Breast Neoplasms; Carcinoma; Epstein-Barr Virus Infections; Lung Neoplasms; Neoplasms; Papillomavirus Infections; Solid tumours; Triple Negative Breast Neoplasms; Urogenital Neoplasms; Vulvar Diseases; Vulvar Neoplasms
Details
TRBC1/2-Targeted CAR-T Cell Therapy (Second Affiliated Hospital School Of Zhejiang University School Of Medicine)Phase 1 ClinicalSecond Affiliated Hospital School Of Zhejiang University School Of MedicineLymphoma, T-Cell, Peripheral
Details
Anti-TRBC1 CAR-T cell therapy (Shanghai General Hospital)Phase 1 ClinicalShanghai General HospitalHematologic Neoplasms
Details
FT-819FT-8198; FT-819; FT 8198Phase 1 ClinicalMemorial Sloan Kettering Cancer CenterLeukemia, Lymphocytic, Chronic, B-Cell; Lupus Erythematosus, Systemic; Lymphoma, B-Cell; Myositis; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Scleroderma, Systemic
Details

Product Reviews

  • 1***82022-08-03
    0People Like
    Human TRBC1 Protein, His Tag (HPLC verified)
    The TRBC1 protein is really helpful! Recently, our experiment has not been smooth UNTIL we used the TRBC1 protein and then things finally started to come together! It turns out we were not using the right protein which stopped us from continuing our project. Thank you so much!
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