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VEGF R1

VEGF R1 Overview

English NameVascular endothelial growth factor receptor 1Approved Drugs13
Drugs in Clinical Trials19Target SynonymFms Related Receptor Tyrosine Kinase 1，EC 2.7.10，EC:2.7.10.1，VEGFR1，Tyrosine-protein kinase receptor FLT，FRT，Fms-like tyrosine kinase 1，FLT1，Fms Related Tyrosine Kinase 1，Vascular Permeability Factor Receptor，Fms-Related Tyrosine Kinase 1 (Vascular Endothelial Growth Factor/Vascular Permeability Factor Receptor)，Vascular Endothelial Growth Factor Receptor 1，Tyrosine-Protein Kinase FRT，VEGFR-1，FLT-1，FLT，Fms-Related Tyrosine Kinase 1，EC 2.7.10.1，Vascular Endothelial Growth Factor Receptor-1
Highest Development StageApproved
English NameVascular endothelial growth factor receptor 1
Target SynonymFms Related Receptor Tyrosine Kinase 1，EC 2.7.10，EC:2.7.10.1，VEGFR1，Tyrosine-protein kinase receptor FLT，FRT，Fms-like tyrosine kinase 1，FLT1，Fms Related Tyrosine Kinase 1，Vascular Permeability Factor Receptor，Fms-Related Tyrosine Kinase 1 (Vascular Endothelial Growth Factor/Vascular Permeability Factor Receptor)，Vascular Endothelial Growth Factor Receptor 1，Tyrosine-Protein Kinase FRT，VEGFR-1，FLT-1，FLT，Fms-Related Tyrosine Kinase 1，EC 2.7.10.1，Vascular Endothelial Growth Factor Receptor-1
Approved Drugs13
Drugs in Clinical Trials19
Highest Development StageApproved

VEGF R1 Product List

  • Product Category

    Protein (4)

  • Product Status

    Launched (4)

  • Species

    Mouse (1)Human (3)

  • Tag

    Mouse IgG Fc Tag (1)His Tag & Avi Tag (1)His Tag (1)Fc Tag (1)

  • Conjugate

    Unconjugated (3)Biotin-labeled (1)

Total: 4
  • 1

VEGF R1 Background

Vascular endothelial growth factor receptor 1 (VEGFR1) is also known as Fms-like tyrosine kinase 1 (FLT-1), Tyrosine-protein kinase receptor FLT, is a single-pass type I membrane protein and secreted protein which belongs to the protein kinase superfamily, Tyr protein kinase family and CSF-1/PDGF receptor subfamily. VEGFR1 is detected in normal lung, but also in placenta, liver, kidney, heart and brain tissues and specifically expressed in most of the vascular endothelial cells, and also expressed in peripheral blood monocytes. VEGFR1 acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. VEGFR1 may play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. VEGFR1 can promote endothelial cell proliferation, survival and angiogenesis in adulthood.

VEGF R1 Synonyms

FLT,VEGFR1,FLT1
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