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VEGF R2

VEGF R2 Overview

English NameVascular endothelial growth factor receptor 2Approved Drugs17
Drugs in Clinical Trials55Target SynonymEC:2.7.10.1，EC 2.7.10，VEGFR2，KDR，Vascular endothelial growth factor receptor 2，Fetal liver kinase 1，Kinase insert domain receptor，Kinase Insert Domain Receptor (A Type III Receptor Tyrosine Kinase)，Protein-Tyrosine Kinase Receptor Flk-1，FLK1，Tyrosine Kinase Growth Factor Receptor，Fetal Liver Kinase-1，Soluble VEGFR2，CD309 Antigen，EC 2.7.10.1，VEGFR-2，CD309，VEGFR，FLK-1，Vascular Endothelial Growth Factor Receptor-2
Highest Development StagePhase 3 Clinical
English NameVascular endothelial growth factor receptor 2
Target SynonymEC:2.7.10.1，EC 2.7.10，VEGFR2，KDR，Vascular endothelial growth factor receptor 2，Fetal liver kinase 1，Kinase insert domain receptor，Kinase Insert Domain Receptor (A Type III Receptor Tyrosine Kinase)，Protein-Tyrosine Kinase Receptor Flk-1，FLK1，Tyrosine Kinase Growth Factor Receptor，Fetal Liver Kinase-1，Soluble VEGFR2，CD309 Antigen，EC 2.7.10.1，VEGFR-2，CD309，VEGFR，FLK-1，Vascular Endothelial Growth Factor Receptor-2
Approved Drugs17
Drugs in Clinical Trials55
Highest Development StagePhase 3 Clinical

VEGF R2 Product List

  • Product Category

    Protein (9)Cell (1)

  • Product Status

    Launched (10)

  • Species

    Human (8)Rhesus macaque (1)Mouse (1)

  • Tag

    His Tag (5)Strep Tag (1)His Tag & Avi Tag (1)Mouse IgG Fc Tag (1)Fc Tag (1)- (1)

  • Conjugate

    Unconjugated (5)Biotin-labeled (1)FITC Labeled (1)- (1)PE Labeled (1)APC Labeled (1)

Total: 10
  • 1

VEGF R2 Background

Kinase insert domain receptor (KDR) is also known as CD309, FLK1, VEGFR, VEGFR2, and is one of the subtypes of VEGFR. VEGF receptors are receptors for vascular endothelial growth factor (VEGF). There are three main subtypes of VEGFR, numbered 1, 2 and 3. The VEGF receptors have an extracellular portion consisting of 7 immunoglobulin-like domains, a single transmembrane spanning region and an intracellular portion containing a split tyrosine-kinase domain. VEGF-A binds to VEGFR-1 (Flt-1) and VEGFR-2 (KDR/Flk-1). VEGFR-2 appears to mediate almost all of the known cellular responses to VEGF.The function of VEGFR-1 is less well defined, although it is thought to modulate VEGFR-2 signaling. Another function of VEGFR-1 may be to act as a dummy/decoy receptor, sequestering VEGF from VEGFR-2 binding (this appears to be particularly important during vasculogenesis in the embryo). In addition, VEGFR2 is able to interact with HIV-1 extracellular Tat protein upon VEGF activation, and seems to enhance angiogenesis in Kaposi's sarcoma lesions.

VEGF R2 Synonyms

KDR,CD309,FLK1,VEGFR,VEGFR2
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