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VEGF165

VEGF165 Overview

English NameVascular endothelial growth factor AApproved Drugs50
Drugs in Clinical Trials60Target SynonymVascular Endothelial Growth Factor，VEGF-A，MVCD1，Vascular endothelial growth factor A，VEGF，VEGFA，VPF，Vascular Endothelial Growth Factor A165，Vascular permeability factor，Vascular Endothelial Growth Factor A121
Highest Development StageApproved
English NameVascular endothelial growth factor A
Target SynonymVascular Endothelial Growth Factor，VEGF-A，MVCD1，Vascular endothelial growth factor A，VEGF，VEGFA，VPF，Vascular Endothelial Growth Factor A165，Vascular permeability factor，Vascular Endothelial Growth Factor A121
Approved Drugs50
Drugs in Clinical Trials60
Highest Development StageApproved

VEGF165 Product List

  • Product Category

    Protein (6)Beads (1)Kits (1)

  • Product Status

    Launched (8)

  • Species

    Human (8)

  • Tag

    Tag Free (3)His Tag (2)His Tag & Avi Tag (1)- (2)

  • Conjugate

    Unconjugated (3)Biotin-labeled (2)FITC Labeled (1)- (2)

Total: 8
  • 1

VEGF165 Background

VEGF165 is the most abundant splice variant of VEGF-A. VEGF165 is produced by a number of cells including endothelial cells, macrophages and T cells. VEGF165 is involved in angiogenesis, vascular endothelial cell survival, growth, migration and vascular permeability. VEGF gene expression is induced by hypoxia, inflammatory cytokines and oncogenes. VEGF165 binds to heparan sulfate and is retained on the cell surface and in the extracellular matrix. VEGF165 binds to the receptor tyrosine kinases, VEGFR1 and VEGFR2. VEGF165 is the only splice variant that binds to co-receptors NRP-1 and NRP-2 that function to enhance VEGFR2 signaling. Binding of VEGF165 to VEGFR1 and VEGFR2 leads to activation of the PI3K/AKT, p38 MAPK, FAK and paxillin. VEGF plays a key role in tumor angiogenesis in many cancers.

VEGF165 Synonyms

RP1-261G23.1,MGC70609,MVCD1,VEGFA,VPF
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