Recombinant Monoclonal Anti-C-MET Antibody, Rabbit (1A1)

Recombinant Monoclonal Anti-C-MET Antibody, Rabbit (1A1) is a C-MET primary antibody for IHC application. MET is a tyrosine kinase receptor for the hepatocyte growth factor. It is linked to functions such as cell proliferation, scattering, morphogenesis, and survival. Ligand binding at the cell surface induces autophosphorylation of MET that provides docking sites for downstream signaling molecules. After activation of the ligand, MET interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3. There interactions lead to the activation of signaling cascades including RAS-ERK, PI3, kinase-AKT, and PLCgamma-PKC. MET plays a role in embryonic development including gastrulation, development of muscles and neurons, angiogenesis, and kidney formation.

Recombinant Monoclonal

1A1

Rabbit IgG, Kappa

Rabbit

Human

React with C-MET protein on the membrane of target cell/tissue

* Recommended dilutions are for reference only. Optimal working concentrations may vary depending on your consumables, reagents, and assay conditions. We recommend optimizing for your specific system. No warranty is made regarding performance at any specific dilution.

Protein A purified.

0.9~1.1 mg/ml

Liquid

Supplied a 0.22 μm-filtered solution in PBS, BSA, Glycerol, with Glycerol as protectant.

Please contact us for customized product forms or formulations.

Liquid product is shipped at blue ice.

Please avoid repeated freeze-thaw cycles.

• 2°C to 8°C for 14 days;
• -20°C to -70°C for 12 months.

Product Specific Notices: For research use only.