PE-Labeled Monoclonal Anti-Human CD279 (PD-1) Antibody, Mouse IgG2b (AS630) (0.03% Proclin)

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FABm044-01-200tests (50tests X 4)
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Source

PE-Labeled Monoclonal Anti-Human CD279 (PD-1) Antibody, Mouse IgG2b (AS630) is a recombinant mouse monoclonal antibody expressed in - cells.

Antibody Type

Recombinant Monoclonal

Clone

AS630

Isotype

Mouse IgG2b, Kappa

Host Species

Mouse

Reactivity

Human

Immunogen

Purified Human CD279 Protein

Conjugate

PE

Excitation Wavelength: 488 nm / 561 nm

Emission Wavelength: 575 nm

Specificity

This product is a specific antibody specifically reacts with CD279 protein.

Application
Application
Recommended Use
Flow Cytometry
1:20

* Recommended dilutions are for reference only. Optimal working concentrations may vary depending on your consumables, reagents, and assay conditions. We recommend optimizing for your specific system. No warranty is made regarding performance at any specific dilution.

Isotype Control

The isotype control is sold separately; please refer to Cat. No. DNP-PM486 for product information.

Concentration

Please refer to the Certificate of Analysis (CoA).

Form

Liquid

Formulation

Supplied a 0.22 μm-filtered solution in PBS (pH 7.4) containing 0.03% ProClin 300 and 0.2% BSA, with trehalose as protectant.

Please contact us for customized product forms or formulations.

Shipping

Liquid product is shipped at blue ice.

Storage

Please protect from light and avoid repeated freeze-thaw cycles.

This product is stable after storage at:
  • Store at 2-8 °C for 12 months.
Notices

Product Specific Notices: For research use only.

Background

CD279, or programmed cell death protein 1 (PD-1), is a 55 kD member of the immunoglobulin superfamily with an immunoreceptor tyrosine-based inhibitory motif (ITIM) in its cytoplasmic region. It is mainly expressed on activated T cells, B cells and myeloid cells, and negatively regulates immune responses by binding to its ligands PD-L1 (B7-H1) and PD-L2 (B7-DC), thereby inhibiting T cell proliferation and cytokine secretion. Dysregulatio of the PD-1 pathway is linked to autoimmune diseases (e.g, rheumatoid arthritis, systemic lupus erythematosus) and tumor immune escape, makin it a key target for cancer immunotherapy. The antibody PE, anti-Human CD279 (PD-1)-AS630 binds specifically to CD279, facilitating relevant research.

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